ArticleTranslational psychiatry2024
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study.
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Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Molecular Modeling of the Pathogenetic Mechanisms of Neuropsychiatric Disorders.International journal of molecular sciences · 2026Review
- Genetic Polymorphisms Associated with Lithium Response in Bipolar Disorder: An Integrative Review and In Silico Protein-Protein Interaction Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Serum Lithium Monitoring, Short-Term Outcomes, and Treatment Barriers in Bipolar Disorder: A Real-World Study.Neuropsychiatric disease and treatment · 2026Article
- Computational Modeling of PI3K/AKT Pathway in Bipolar Disorder and Type 2 Diabetes: Implications for Lithium Treatment and Curcumin as a Potential Alternative.International journal of molecular sciences · 2025Article
- Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia.Molecular psychiatry · 2025Article
- Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.Biological psychiatry global open science · 2025Article
- The Mechanisms of Lithium Action: The Old and New Findings.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The Potential of Using Screening Tools for Bipolar Disorder to Predict Lithium Response.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Exosomal microRNA signatures in youth at clinical high risk for bipolar disorder.Frontiers in psychiatry · 2025Article
- Converging evidence for functional connections between the lithium response and PI3K-Akt signaling.Translational psychiatry · 2024Article
- Navigating the Neuroimmunomodulation Frontier: Pioneering Approaches and Promising Horizons-A Comprehensive Review.International journal of molecular sciences · 2024Review
- Pharmacogenomics and response to lithium in bipolar disorder.Pharmacogenomics · 2024Review
- Identification of significant biomarkers for predicting the risk of bipolar disorder with arteriosclerosis based on integrative bioinformatics and machine learning.Frontiers in psychiatry · 2024Article
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Authors and funding
125 authors at 20 institutions in 19 countries.
Anna H OuDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0006-0714-1684
Sara B RosenthalCenter for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Mazda AdliDepartment of Psychiatry and Psychotherapy, Charité- Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Kazufumi AkiyamaDepartment of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan.
Nirmala AkulaIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0001-9544-3944
Azmeraw T AmareDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-7940-0335
Raffaella ArdauUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Bárbara AriasDepartment of Evolutive Biology, Ecology and Environmental Sciences, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0001-9181-2132
Jean-Michel AubryDepartment of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.
Lena BacklundDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-2666-859X
Bernhard T BauneDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0001-6548-426X
Frank BellivierINSERM UMR-S 1144-Université Paris Cité Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.
Antonio BenabarreBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain.
Susanne BengesserNeurobiological Background and Anthropometrics in Bipolar Affective Disorder, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Abesh Kumar BhattacharjeeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Joanna M BiernackaDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9350-4440
Pablo CervantesThe Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada.
Guo-Bo ChenThe Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada.
Hsi-Chung ChenDepartment of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0003-3191-0093
Caterina ChillottiUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Sven CichonInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Scott R ClarkDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0003-1640-5611
Francesc ColomBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain.
David A CousinsCampus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.
Cristiana CruceanuDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada.ORCID 0000-0002-7799-5531
Piotr M CzerskiPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0003-0745-5916
Clarissa R DantasDepartment of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil.
Alexandre DayerDepartment of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.
Maria Del ZompoUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.ORCID 0000-0001-9491-5938
Franziska DegenhardtInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
J Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-9221-9226
Bruno ÉtainINSERM UMR-S 1144-Université Paris Cité Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.ORCID 0000-0002-5377-1488
Peter FalkaiInstitute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Munich, Germany.
Frederike Tabea FellendorfNeurobiological Background and Anthropometrics in Bipolar Affective Disorder, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Ewa Ferensztajn-RochowiakDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.ORCID 0000-0002-1876-6368
Louise FrisénDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-6997-4215
Janice M FullertonMental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia.ORCID 0000-0003-4014-4490
Sébastien GardPôle de Psychiatrie Générale Universitaire, Centre Hospitalier Charles Perrens, Bordeaux, France.
Julie S GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0002-7987-4995
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, Bucharest, Romania.ORCID 0000-0002-1304-6687
Paul GrofMood Disorders Center of Ottawa, Ottawa, ON, Canada.
Oliver GruberDepartment of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
Ryota HashimotoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID 0000-0002-5941-4238
Joanna HauserPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0002-6621-3493
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Munich, Germany.ORCID 0000-0001-7135-762X
Stefan HermsInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Andrea HofmannInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Liping HouIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.ORCID 0000-0003-3972-245X
Stephane JamainInserm U955, Psychiatrie Translationnelle, Créteil, France.ORCID 0000-0002-4321-4100
Esther JiménezBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain.
Jean-Pierre KahnService de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Laxou-Université de Lorraine, Nancy, France.
Layla KassemIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Tadafumi KatoLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.ORCID 0000-0001-7856-3952
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany.
Barbara KönigDepartment of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
Po-Hsiu KuoInstitute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0003-0365-3587
Ichiro KusumiDepartment of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.ORCID 0000-0002-8747-5070
Nina LacknerNeurobiological Background and Anthropometrics in Bipolar Affective Disorder, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Gonzalo LajeIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Mikael LandénInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.ORCID 0000-0002-4496-6451
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-4987-2718
Marion LeboyerAssistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France.ORCID 0000-0001-5473-3697
Susan G LeckbandDepartment of Pharmacy, VA San Diego Healthcare System, La Jolla, CA, USA.
Carlos A López JaramilloDepartment of Psychiatry, University of Antioquia, Medellín, Medellín, Colombia.
Glenda MacQueenDepartment of Psychiatry, University of Calgary, Calgary, AB, Canada.
Mario MajDepartment of Psychiatry, University of Naples SUN, Naples, Italy.
Mirko ManchiaDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.ORCID 0000-0003-4175-6413
Cynthia Marie-ClaireINSERM UMR-S 1144-Université Paris Cité Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.ORCID 0000-0002-2282-134X
Lina MartinssonDepartment of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
Manuel MattheisenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Michael J McCarthyDepartment of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, USA.
Susan L McElroyDepartment of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, OH, USA.
Francis J McMahonIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.ORCID 0000-0002-9469-305X
Philip B MitchellSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.ORCID 0000-0002-7954-5235
Marina MitjansDepartment of Genetics, Microbiology, and Statistics, Faculty of Biology and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, CIBER de Salud Mental, ISCIII, Madrid, Spain.ORCID 0000-0001-5543-7320
Francis M MondimoreDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Palmiero MonteleoneNeurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-5766-8923
Markus M NöthenInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.ORCID 0000-0002-8770-2464
Tomas NovákNational Institute of Mental Health, Klecany, Czech Republic.ORCID 0000-0001-9156-9654
Urban ÖsbyDepartment of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Norio OzakiDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-7360-4898
Sergi PapiolLudwig-Maximilians-University of Munich, Munich, Germany.ORCID 0000-0001-9366-8728
Roy H PerlisDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Claudia PisanuDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
James B PotashDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Daniela Reich-ErkelenzInstitute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Munich, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany.ORCID 0000-0002-0992-634X
Eva Z ReininghausNeurobiological Background and Anthropometrics in Bipolar Affective Disorder, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.ORCID 0000-0001-5964-4087
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0002-5236-6149
Guy A RouleauMontreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0001-8403-1418
Janusz K RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0003-0577-0381
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-5011-2922
Peter R SchofieldMental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia.ORCID 0000-0003-2967-9662
K Oliver SchubertDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0003-1690-0209
Thomas G SchulzeIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.ORCID 0000-0001-6624-2975
Barbara W SchweizerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Florian SeemüllerInstitute of Psychiatric Phenomics and Genomics (IPPG) and Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Munich, Germany.
Giovanni SeverinoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.ORCID 0000-0002-6354-2662
Tatyana ShekhtmanDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Paul D ShillingDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0129-5504
Kazutaka ShimodaDepartment of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan.ORCID 0000-0002-9663-6243
Christian SimhandlBipolar Center, Wiener Neustadt, Austria.
Claire M SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.ORCID 0000-0001-7415-7607
Thomas StammDepartment of Psychiatry and Psychotherapy, Charité- Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Pavla StopkovaNational Institute of Mental Health, Klecany, Czech Republic.
Sarah K TigheDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Alfonso TortorellaDepartment of Psychiatry, University of Naples SUN, Naples, Italy.
Gustavo TureckiDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada.ORCID 0000-0003-4075-2736
Eduard VietaBipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain.ORCID 0000-0002-0548-0053
Julia VolkertDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany.
Stephanie WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID 0000-0002-1571-1468
Naomi R WrayThe University of Queensland, Queensland Brain Institute, Brisbane, QLD, Australia.ORCID 0000-0001-7421-3357
Adam WrightSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.
L Trevor YoungDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Peter P ZandiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
John R KelsoeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA. jkelsoe@health.ucsd.edu.
University of Bonn · DEUnited States Department of Health and Human Services · USUniversity of Cagliari · ITUniversity of California San Diego · USCentro de Investigación Biomédica en Red de Salud Mental · ESJohns Hopkins University · USKarolinska University Hospital · SELudwig-Maximilians-Universität München · DEDalhousie University · CAInserm · FRMedical University of Graz · ATPoznan University of Medical Sciences · PLGoethe University Frankfurt · DEMontreal Neurological Institute and Hospital · CAThe University of Adelaide · AUBlack Dog Institute · AUDokkyo Medical University · JPDouglas Mental Health University Institute · CAHeidelberg University · DEKarolinska Institutet · SE
Funding
Identification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5MThe Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MPharmacogenomics of Mood Stabilizer Response in Bipolar DisorderU01MH092758 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2010 to 2014
$6.2MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059534 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1998 to 2007
$3.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059545 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 1998 to 2007
$2.6MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059533 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACKINNON, DEAN FREDERICK · 1998 to 2007
$2.4MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH060068 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1998 to 2007
$2.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059553 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BERRETTINI, WADE H · 1998 to 2007
$2.1MMapping genes that contribute to bipolar disorderZ01MH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2003 to 2008
$2.0MCollaborative Genomic Study of Bipolar DisorderR01MH059548 · NIMH · UNIVERSITY OF IOWA · PI CORYELL, WILLIAM HENRY · 1998 to 2007
$1.9MCOLLABORATIVE STUDY OF BIPOLAR DISORDERR01MH059535 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S · 1998 to 2007
$1.9MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059567 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 1998 to 2007
$1.8MBLRD VA I01 BX003431Intramural NIH HHS Z01 MH002810Medical Research Council MR/L006642/1NCI NIH HHS P01 CA089392NIDA NIH HHS K02 DA021237NIMH NIH HHS R01 MH059533NIMH NIH HHS R01 MH059534NIMH NIH HHS R01 MH059535NIMH NIH HHS R01 MH059545NIMH NIH HHS R01 MH059548NIMH NIH HHS R01 MH059553NIMH NIH HHS R01 MH059556NIMH NIH HHS R01 MH059567NIMH NIH HHS R01 MH060068NIMH NIH HHS U01 MH092758
Abstract
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
Indexed as
Bipolar DisorderLithiumFocal AdhesionsGenome-Wide Association StudyHumansMultiomicsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktLithiumPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt
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