Evidence map›Paper›PMID 38395839›Full record

ArticleBMC nephrology2024

PLA2R-positive membranous nephropathy in IgG4-related disease.

Yusuke Ushio, Taro Akihisa, Kazunori Karasawa, Momoko Seki, Shizuka Kobayashi, Yoei Miyabe, Hiroshi Kataoka, Naoko Ito, Sekiko Taneda, Shin'ichi Akiyama and 4 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Yusuke UshioDepartment of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan. ushio.yusuke@twmu.ac.jp.
Taro AkihisaDepartment of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Kazunori KarasawaDepartment of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Momoko SekiDepartment of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Shizuka KobayashiDepartment of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Yoei MiyabeDepartment of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Hiroshi KataokaDepartment of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Naoko ItoDepartment of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.
Sekiko TanedaDepartment of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.
Shin'ichi AkiyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Akira HebisawaClinical Research Center, National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Mitsuhiro KawanoDepartment of Rheumatology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Kazuho HondaDepartment of Anatomy, Showa University School of Medicine, Tokyo, Japan.
Junichi HoshinoDepartment of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Tokyo Women's Medical University · JPKanazawa University · JPNagoya University · JPShowa University · JPTokyo National Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIgG4-related disease (IgG4-RD) is a fibroinflammatory disease that affects multiple organs, including the pancreas, lacrimal glands, salivary glands, periaortic/retroperitoneum, and kidney. Interstitial nephritis is a typical renal disorder associated with IgG4-RD, but membranous nephropathy is also seen in some cases. CASE PRESENTATION: Herein we report on the case of a 77-year-old male patient with nephrotic syndrome and IgG4-related lung disease. His serum phospholipase A2 receptor (PLA2R) antibody was positive. His renal biopsy specimen was also positive for PLA2R. The renal biopsy specimen showed membranous nephropathy with equal IgG3 and IgG4 immunofluorescence staining and no interstitial nephritis, suggesting IgG4-RD manifesting as membranous nephropathy.

conclusionsNephrotic syndrome caused by membranous nephropathy is sometimes associated with IgG4-RD. In such cases, even if serum PLA2R antibody is positive, it should be considered that the membranous nephropathy may be secondary to IgG4-RD.

Indexed as

Glomerulonephritis, MembranousImmunoglobulin G4-Related DiseaseNephritis, InterstitialNephrotic SyndromeAgedAutoantibodiesHumansImmunoglobulin GMaleReceptors, Phospholipase A2AutoantibodiesImmunoglobulin GReceptors, Phospholipase A2IgG4-related DiseasePLA2R-positive membranous nephropathy

Identifiers

PMID38395839
PMCPMC10893645
OpenAlexW4392092368

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.