Evidence map›Paper›PMID 38395805›Full record

ArticleBMC psychiatry2024

The genetic architecture of youth anxiety: a study protocol.

Laina McAusland, Christie L Burton, Alexa Bagnell, Khrista Boylan, Taylor Hatchard, Patricia Lingley-Pottie, Abdullah Al Maruf, Patrick McGrath, Amanda S Newton, Karen Rowa and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Laina McAuslandThe Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. lbsorens@ucalgary.ca.
Christie L BurtonNeurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada.
Alexa BagnellDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Khrista BoylanDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Taylor HatchardDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Patricia Lingley-PottieDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Abdullah Al MarufThe Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Patrick McGrathDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Amanda S NewtonDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Karen RowaDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Russell J SchacharNeurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada.
S-M ShaheenThe Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Sam StewartDepartment of Epidemiology and Community Health, Dalhousie University, Halifax, NS, Canada.
Paul D ArnoldThe Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Jennifer CrosbieNeurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada.
Manuel MattheisenDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Noam SoreniDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
S Evelyn StewartBritish Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
Sandra MeierDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Dalhousie University · CAUniversity of Calgary · CAChild Development Center · QASt. Joseph’s Healthcare Hamilton · CAUniversity of Toronto · CAHospital for Sick Children · CAUniversity of Alberta · CA

Funding

CIHR CIHR: PJT-180339
6 · The paper itself

Abstract

backgroundAnxiety disorders are the most common psychiatric problems among Canadian youth and typically have an onset in childhood or adolescence. They are characterized by high rates of relapse and chronicity, often resulting in substantial impairment across the lifespan. Genetic factors play an important role in the vulnerability toward anxiety disorders. However, genetic contribution to anxiety in youth is not well understood and can change across developmental stages. Large-scale genetic studies of youth are needed with detailed assessments of symptoms of anxiety disorders and their major comorbidities to inform early intervention or preventative strategies and suggest novel targets for therapeutics and personalization of care.

methodsThe Genetic Architecture of Youth Anxiety (GAYA) study is a Pan-Canadian effort of clinical and genetic experts with specific recruitment sites in Calgary, Halifax, Hamilton, Toronto, and Vancouver. Youth aged 10-19 (n = 13,000) will be recruited from both clinical and community settings and will provide saliva samples, complete online questionnaires on demographics, symptoms of mental health concerns, and behavioural inhibition, and complete neurocognitive tasks. A subset of youth will be offered access to a self-managed Internet-based cognitive behavioral therapy resource. Analyses will focus on the identification of novel genetic risk loci for anxiety disorders in youth and assess how much of the genetic risk for anxiety disorders is unique or shared across the life span. DISCUSSION: Results will substantially inform early intervention or preventative strategies and suggest novel targets for therapeutics and personalization of care. Given that the GAYA study will be the biggest genomic study of anxiety disorders in youth in Canada, this project will further foster collaborations nationally and across the world.

Indexed as

AnxietyAnxiety DisordersAdolescentCanadaHumansMental HealthRisk FactorsAnxiety disordersChild & adolescent psychiatryGenetics

Identifiers

PMID38395805
PMCPMC10885620
OpenAlexW4392106399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.