Evidence map›Paper›PMID 38395612›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Conditional Deletion of β-Catenin in the Mediobasal Hypothalamus Impairs Adaptive Energy Expenditure in Response to High-Fat Diet and Exacerbates Diet-Induced Obesity.

Mohammed Z Rizwan, Kaj Kamstra, Dominik Pretz, Peter R Shepherd, Alexander Tups, David R Grattan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mohammed Z RizwanCentre for Neuroendocrinology and Department of Anatomy, University of Otago School of Biomedical Sciences, Dunedin 9016, New Zealand.
Kaj KamstraCentre for Neuroendocrinology and Department of Physiology, University of Otago School of Biomedical Sciences, Dunedin 9016, New Zealand.
Dominik PretzCentre for Neuroendocrinology and Department of Physiology, University of Otago School of Biomedical Sciences, Dunedin 9016, New Zealand.
Peter R ShepherdMaurice Wilkins Centre for Molecular Biodiscovery, Auckland 1010, New Zealand.
Alexander TupsMaurice Wilkins Centre for Molecular Biodiscovery, Auckland 1010, New Zealand.
David R GrattanCentre for Neuroendocrinology and Department of Anatomy, University of Otago School of Biomedical Sciences, Dunedin 9016, New Zealand dave.grattan@otago.ac.nz.ORCID 0000-0001-5606-2559
Maurice Wilkins Centre · NZUniversity of Otago · NZUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-Catenin is a bifunctional molecule that is an effector of the wingless-related integration site (Wnt) signaling to control gene expression and contributes to the regulation of cytoskeleton and neurotransmitter vesicle trafficking. In its former role, β-catenin binds transcription factor 7-like 2 (TCF7L2), which shows strong genetic associations with the pathogenesis of obesity and type-2 diabetes. Here, we sought to determine whether β-catenin plays a role in the neuroendocrine regulation of body weight and glucose homeostasis. Bilateral injections of adeno-associated virus type-2 (AAV2)-mCherry-Cre were placed into the arcuate nucleus of adult male and female β-catenin

Indexed as

Diabetes Mellitus, Type 2Diet, High-Fatalpha CateninAnimalsbeta CateninBody WeightEnergy MetabolismFemaleGlucoseHypothalamusLeptinMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue Proteinsalpha Cateninbeta CateninCtnna2 protein, mouseGlucoseLeptinNerve Tissue Proteinsarcuate nucleusenergy expenditurefood intakehypothalamusobesityβ-catenin

Identifiers

PMID38395612
PMCPMC10993030
OpenAlexW4392094245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.