Evidence map›Paper›PMID 38395192›Full record

ArticleJournal of pediatric and adolescent gynecology2024

Ovarian Morphology in Girls Longitudinal Cohort Study: Pilot Evaluation of Ovarian Morphology as a Biomarker of Reproductive and Metabolic Features during the First Gynecological Year.

Heidi Vanden Brink, Tania S Burgert, Romina Barral, Anushka Malik, Manasa Gadiraju, Marla E Lujan

Abstract read
In one paragraph

Article in Journal of pediatric and adolescent gynecology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Heidi Vanden BrinkDivision of Nutritional Sciences, Cornell University, Ithaca, New York; Division of Endocrinology, Children's Mercy Kansas City, Kansas City, Missouri; Department of Nutrition, Texas A&M University, College Station, Texas. Electronic address: heidi.vandenbrink@ag.tamu.edu.
Tania S BurgertDivision of Endocrinology, Children's Mercy Kansas City, Kansas City, Missouri.
Romina BarralDivision of Adolescent Medicine, Children's Mercy Kansas City, Kansas City, Missouri; University of Missouri Kansas City School of Medicine, Kansas City, Missouri; University of Kansas Medical Center, Kansas City, Kansas.
Anushka MalikDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Manasa GadirajuUniversity of Missouri Kansas City School of Medicine, Kansas City, Missouri.
Marla E LujanDivision of Nutritional Sciences, Cornell University, Ithaca, New York. Electronic address: marla.lujan@cornell.edu.

Funding

Reducing reproductive health disparities among Latinx youth living in rural communitiesK23HD109464 · NICHD · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Romina Loreley Barral · 2022 to 2026
$809k
Trajectory of ovarian morphology during the adolescent reproductive transition.R21HD095372 · NICHD · CORNELL UNIVERSITY · PI LUJAN, MARLA E · 2019 to 2020
$436k
NICHD NIH HHS K23 HD109464NICHD NIH HHS R21 HD095372
6 · The paper itself

Abstract

objectiveThe objective was to establish whether aspects of ovarian morphology correlate with reproductive and metabolic features during the first postmenarcheal year using data from the Ovarian Morphology in Girls (OMG!) cohort study. The feasibility of transabdominal ultrasonography to assess ovarian features was also determined.

methodsHealthy adolescent females enrolled in a prospective cohort study. Study visits occurred at 6-10, 11-13, 17-19, and 23-25 months postmenarche and entailed a physical exam, transabdominal ultrasound, and fasting blood draw. Participants maintained menstrual diaries throughout the study. The present analysis reflects participants who completed the study visit at 6-10 months postmenarche. Associations between ovarian morphology or average cycle length with reproductive and metabolic features were assessed by Spearman correlations and linear regression.

resultsForty participants enrolled in the OMG! STUDY: Thirty-one participants initiated study procedures at 6-10 months postmenarche, and data were available for analysis for 29 participants. Image quality was judged as partially visible or excellent in 90% of the left and 78% of the right ovaries assessed, with all images collected having sufficient image quality to provide measurements of at least 1 ovarian marker. The follicle number per ovary and ovarian volume were positively associated with anti-Müllerian hormone levels and negatively associated with fasting insulin. The average cycle length was only associated negatively with triglycerides.

conclusionTransabdominal ultrasonography in the early postmenarcheal period provides sufficient resolution to enable estimations of antral follicle count and ovarian size. Ovarian features in early gynecological life may correspond with measures of reproductive and metabolic function.

Indexed as

OvaryUltrasonographyAdolescentAnti-Mullerian HormoneBiomarkersChildCohort StudiesFemaleHumansInsulinLongitudinal StudiesOvarian FolliclePilot ProjectsProspective StudiesAnti-Mullerian HormoneBiomarkersInsulinAdolescenceMenarcheMenstrual cycleOvaryUltrasound

Identifiers

PMID38395192
PMCPMC11195913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.