Evidence map›Paper›PMID 38394867›Full record

ArticleSchizophrenia research2024

Interplay between childhood trauma, bodily self-disturbances, and clinical phenomena in schizophrenia spectrum disorders: A network analysis.

Lénie J Torregrossa, Jinyuan Liu, Kristan Armstrong, Stephan Heckers, Julia M Sheffield

Open access · greenAbstract read
In one paragraph

Article in Schizophrenia research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lénie J TorregrossaVanderbilt University Medical Center, Department of Psychiatry and Behavioral Sciences, United States of America. Electronic address: lenie.torregrossa@ucsf.edu.
Jinyuan LiuVanderbilt University Medical Center, Department of Biostatistics, United States of America.
Kristan ArmstrongVanderbilt University Medical Center, Department of Psychiatry and Behavioral Sciences, United States of America.
Stephan HeckersVanderbilt University Medical Center, Department of Psychiatry and Behavioral Sciences, United States of America.
Julia M SheffieldVanderbilt University Medical Center, Department of Psychiatry and Behavioral Sciences, United States of America.
Vanderbilt University Medical Center · US

Funding

Imaging Hippocampal Function in PsychosisR01MH070560 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HECKERS, STEPHAN · 2005 to 2025
$7.2M
Cognitive mechanisms of delusion severity throughout recovery from a psychotic episode: a computational approachK23MH126313 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHEFFIELD, JULIA MAY · 2021 to 2025
$821k
NIMH NIH HHS K23 MH126313NIMH NIH HHS R01 MH070560
6 · The paper itself

Abstract

backgroundBodily self-disturbances have long been considered central to schizophrenia. Exposure to childhood trauma has been linked to the development of both psychosis and bodily self-disturbances, yet little work has examined the role of bodily self-disturbances in the relationship between childhood trauma and schizophrenia symptomatology. This study uses network analysis to bridge this gap.

methodsNetworks were constructed to examine relationships between schizophrenia symptoms (Positive and Negative Symptom Scale; PANSS), bodily self-disturbances (Perceptual Aberration Scale; PAS), and self-reported exposure to childhood trauma (Childhood Trauma Questionnaire, Short-Form; CTQ-SF) in 152 people with a schizophrenia-spectrum disorder. Shortest path and bridge analyses were conducted to assess the role of bodily self-disturbances in linking childhood trauma to schizophrenia symptomatology. Three networks were constructed: 1) PAS, childhood trauma, and PANSS sub-scale composites (positive, negative, general); 2) PAS, childhood trauma, and positive symptoms, 3) PAS, childhood trauma, and distress symptoms.

resultsShortest path analysis revealed that bodily self-disturbances were on the shortest path between childhood trauma and positive and general symptoms (Network 1), between trauma and hallucinations (Network 2), and between trauma and depression (Network 3). Bodily self-disturbances were also found to serve as a bridge between childhood trauma and positive symptoms of schizophrenia, particularly delusions and hallucinations.

conclusionsUsing a novel, data-driven approach, we showed that bodily self-disturbances play a key role in linking childhood trauma to positive and co-morbid affective symptoms of schizophrenia. Threat experiences (i.e., abuse) specifically relate to bodily self-disturbances and psychotic symptoms.

Indexed as

Adverse Childhood ExperiencesPsychological TestsPsychotic DisordersSchizophreniaSelf ReportChildHallucinationsHumansBodily self-disturbancesChildhood traumaMechanistic pathwaysNetwork analysisSchizophrenia

Identifiers

PMID38394867
PMCPMC11737823
OpenAlexW4392023581

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.