ReviewProceedings of the National Academy of Sciences of the United States of America2024
The sleep-circadian interface: A window into mental disorders.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A Systematic Review on Insomnia and Circadian Rhythms Desynchronization in Obsessive-Compulsive Disorder: From Childhood to Adulthood.Journal of sleep research · 2026Pooled it
- A systematic review of epidemiological studies into daylight-saving time & health identifying beneficial & adverse effects.European journal of epidemiology · 2026Pooled it
- Transdiagnostic effects of combined sleep-circadian interventions on depressive symptoms and sleep outcomes in adults with mental disorders: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2026Pooled it
- The dose-effect relationship between acupuncture and its effect on primary insomnia: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Monitoring Daily Sleep, Mood, and Affect Using Digital Technologies and Wearables: A Systematic Review.Sensors (Basel, Switzerland) · 2024Pooled it
- Longer Sleep Duration Predicts Progression to Bipolar or Psychotic Disorders in Youth Accessing Early Intervention Mental Health Services.Bipolar disorders · 2026Article
- Considerations and guidelines for photic measurement in field studies of the physiological effects of light.Npj biological timing and sleep · 2026Review
- Young minds in distress: Exploring the global rise in youth mental health diagnoses.Molecular psychiatry · 2026Review
- Developing multicomponent chronotherapeutic interventions for emerging adults with delayed sleep timing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness.Molecular psychiatry · 2026Article
- Automated Multimodal Sleep Staging Using DWT-Based Wavelet Decomposition and Explainable Machine Learning with Signal Sculpting Topographies.Diagnostics (Basel, Switzerland) · 2026Article
- Sleep and light ecologies of parents with young infants: descriptive findings from the SUNSHINE project.Npj biological timing and sleep · 2026Article
- Temporal Patterns of Engagement and Sentiment in a Suicide Prevention Mobile App: Three-Year Observational Study.JMIR mental health · 2026Observational
- The association between sleep spindles and cognitive performance in euthymic bipolar disorder.Translational psychiatry · 2026Article
- The Interactions Between Circadian Rhythm, Gut Microbiota, and Anxiety: From Mechanisms to Intervention Strategies.Nutrients · 2026Review
- Suicide and Sleep Disorders: The Role of Insomnia, Nightmares, and Circadian Disruption.Cureus · 2026Review
- Targeting Sleep to Improve Outcomes in Psychosis: Digital and Non-Pharmacological Interventions.Medicina (Kaunas, Lithuania) · 2026Review
- Sleep and Circadian Rhythms in Patients with Physical and Mental Disorders.Journal of clinical medicine · 2026Article
- Sleep as a moderator of adolescent brain development-evidence from a longitudinal MRI study.Sleep · 2026Article
- A machine-learning-derived online screening tool for depressive symptoms in chronic digestive system diseases patients: a cross-sectional study with temporal validation from CHARLS.Scientific reports · 2026Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances can alleviate psychopathology. Conversely, psychiatric symptoms can reciprocally exacerbate poor sleep and disrupt clock-controlled processes. Despite progress in elucidating underlying mechanisms, a cohesive approach that integrates the dynamic interactions between psychiatric disorder with both sleep and circadian processes is lacking. This review synthesizes recent evidence for sleep-circadian dysfunction as a transdiagnostic contributor to a range of psychiatric disorders, with an emphasis on biological mechanisms. We highlight observations from adolescent and young adults, who are at greatest risk of developing mental disorders, and for whom early detection and intervention promise the greatest benefit. In particular, we aim to a) integrate sleep and circadian factors implicated in the pathophysiology and treatment of mood, anxiety, and psychosis spectrum disorders, with a transdiagnostic perspective; b) highlight the need to reframe existing knowledge and adopt an integrated approach which recognizes the interaction between sleep and circadian factors; and c) identify important gaps and opportunities for further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.