Evidence map›Paper›PMID 38394242›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria.

Yasuhiro Kamii, Koji Hayashizaki, Toshio Kanno, Akio Chiba, Taku Ikegami, Mitsuru Saito, Yukihiro Akeda, Toshiaki Ohteki, Masato Kubo, Kiyotsugu Yoshida and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026
    Review
  2. Review
  3. [Research progress on the role of invariant natural killer T cells in immune-mediated liver injury].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  4. Review
  5. Review
  6. IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Yasuhiro Kamii *Department of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0000-0002-3192-050X
Koji Hayashizaki *Department of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Toshio KannoDepartment of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute, Chiba 292-0818, Japan.
Akio ChibaDepartment of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Taku IkegamiDepartment of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Mitsuru SaitoDepartment of Orthopaedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0000-0003-1653-4309
Yukihiro AkedaDepartment of Bacteriology I, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Toshiaki OhtekiDepartment of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.ORCID 0000-0002-8088-5165
Masato KuboDivision of Molecular Pathology, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba 278-0022, Japan.
Kiyotsugu YoshidaDepartment of Biochemistry, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0000-0003-3108-7383
Kazuyoshi KawakamiDepartment of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
Kazunori OishiToyama Institute of Health, Toyama 939-0363, Japan.
Jun ArayaDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Kazuyoshi KuwanoDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Mitchell KronenbergLa Jolla Institute for Immunology, La Jolla, CA 92037.ORCID 0000-0001-6318-6445
Yusuke EndoDepartment of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute, Chiba 292-0818, Japan.ORCID 0000-0002-7223-1938
Yuki KinjoDepartment of Bacteriology, The Jikei University School of Medicine, Tokyo 105-8461, Japan.ORCID 0000-0001-9915-7013
Jikei University School of Medicine · JPKazusa DNA Research Institute · JPLa Jolla Institute for Immunology · USNational Institute of Infectious Diseases · JPTohoku University · JPTokyo Medical and Dental University · JPTokyo University of Science · JPToyama Institute of Health · JP

Funding

Development and Function of NKT CellsR37AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2006 to 2015
$4.9M
NIAID NIH HHS R37 AI071922The Ministry of Education, Culture, Sports, Science and Technology (Japan) #19K16704 #21K07085The Ministry of Education, Culture, Sports, Sciences and Technology (Japan) #19H03705 #22H03123
6 · The paper itself

Abstract

Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that express an invariant T cell receptor α chain and contribute to bridging innate and acquired immunity with rapid production of large amounts of cytokines after stimulation. Among effecter subsets of iNKT cells, follicular helper NKT (NKT

Indexed as

Interleukin-27Natural Killer T-CellsAnimalsCell DifferentiationCytokinesMiceMice, Inbred C57BLT-Lymphocytes, Helper-InducerCytokinesInterleukin-27follicular helperIL-27iNKTmitochondrial metabolismStreptococcus pneumoniae

Identifiers

PMID38394242
PMCPMC10907256
OpenAlexW4392094271

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.