ArticleProceedings of the National Academy of Sciences of the United States of America2024
A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) in
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Cross-Species Social Experience Suppresses Aggression in Drosophila.Neuroscience bulletin · 2026Article
- Space-Dependent Oviposition Preference in Drosophila.Neuroscience bulletin · 2026Article
- Sleep regulation inFrontiers in neuroscience · 2026Review
- Article
- Chemosensation drives divergent social behavior in Drosophila.Communications biology · 2025Article
- Social experience shapes fighting strategies ineLife · 2025Article
- Comparative Perspectives on Neuropeptide Function and Social Isolation.Biological psychiatry · 2025Review
- A brief history of insect neuropeptide and peptide hormone research.Cell and tissue research · 2025Review
- Review
- Socialization causes long-lasting behavioral changes.Scientific reports · 2024Article
- Recovery from social isolation requires dopamine in males, but not the autism-related geneRoyal Society open science · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Social enrichment or social isolation affects a range of innate behaviors, such as sex, aggression, and sleep, but whether there is a shared mechanism is not clear. Here, we report a neural mechanism underlying social modulation of spontaneous locomotor activity (SoMo-SLA), an internal-driven behavior indicative of internal states. We find that social enrichment specifically reduces spontaneous locomotor activity in male flies. We identify neuropeptides Diuretic hormone 44 (DH44) and Tachykinin (TK) to be up- and down-regulated by social enrichment and necessary for SoMo-SLA. We further demonstrate a sexually dimorphic neural circuit, in which the male-specific P1 neurons encoding internal states form positive feedback with interneurons coexpressing
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.