Evidence map›Paper›PMID 38394193›Full record

ArticleScience advances2024

Accumulation of defense systems in phage-resistant strains of

Ana Rita Costa, Daan F van den Berg, Jelger Q Esser, Aswin Muralidharan, Halewijn van den Bossche, Boris Estrada Bonilla, Baltus A van der Steen, Anna C Haagsma, Ad C Fluit, Franklin L Nobrega and 2 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
35.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 79 citations in OpenAlex.

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  10. Intracellular barriers and receptor masking limit success of abioRxiv : the preprint server for biology · 2026
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  19. Realizing phage therapy in the UK.Nature microbiology · 2026
    Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ana Rita CostaDepartment of Bionanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.ORCID 0000-0001-6749-6408
Daan F van den BergDepartment of Bionanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.ORCID 0000-0002-2217-4074
Jelger Q EsserDepartment of Bionanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.ORCID 0000-0003-4857-8584
Aswin MuralidharanDepartment of Bionanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.ORCID 0000-0003-2240-4260
Halewijn van den BosscheDepartment of Bionanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.ORCID 0000-0002-6801-5167
Boris Estrada BonillaDepartment of Bionanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.ORCID 0000-0002-3346-3090
Baltus A van der SteenDepartment of Bionanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.ORCID 0000-0001-8193-4814
Anna C HaagsmaDepartment of Bionanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.ORCID 0000-0001-7656-3932
Ad C FluitMedical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.ORCID 0000-0003-3432-0021
Franklin L NobregaSchool of Biological Sciences, University of Southampton, SO17 1BJ Southampton, UK.ORCID 0000-0002-8238-1083
Pieter-Jan HaasMedical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.
Stan J J BrounsDepartment of Bionanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.ORCID 0000-0002-9573-1724
Delft University of Technology · NLUtrecht University · NLUniversity of Southampton · GB

Funding

European Research Council
6 · The paper itself

Abstract

Prokaryotes encode multiple distinct anti-phage defense systems in their genomes. However, the impact of carrying a multitude of defense systems on phage resistance remains unclear, especially in a clinical context. Using a collection of antibiotic-resistant clinical strains of

Indexed as

BacteriophagesPseudomonas InfectionsPseudomonas PhagesAnti-Bacterial AgentsHumansPseudomonas aeruginosaAnti-Bacterial Agents

Identifiers

PMID38394193
PMCPMC10889362
OpenAlexW4392094078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.