Evidence map›Paper›PMID 38393667›Full record

ArticleStem cell reviews and reports2024

Exosomes Derived from Adipose Stem Cells Enhance Angiogenesis in Diabetic Wound Via miR-146a-5p/JAZF1 Axis.

Dehui Che, Xinjian Xiang, Juan Xie, Zenghong Chen, Qiong Bao, Dongsheng Cao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reviews and reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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  18. Exosomal miR-155-5p promote the occurrence of carotid atherosclerosis.Journal of cellular and molecular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dehui Che *Department of Plastic and Reconstructive, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Xinjian Xiang *Department of Plastic and Reconstructive, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Juan XieDepartment of Plastic and Reconstructive, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Zenghong ChenDepartment of Plastic and Reconstructive, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Qiong BaoDepartment of Plastic and Reconstructive, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Dongsheng CaoDepartment of Plastic and Reconstructive, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. aesthetic12345@sina.com.ORCID 0009-0004-1342-2410
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic trauma in diabetes is a leading cause of disability and mortality. Exosomes show promise in tissue regeneration. This study investigates the role of exosomes derived from adipose stem cells (ADSC-Exos) in angiogenesis. MiRNA-seq analysis revealed significant changes in 47 genes in human umbilical vein endothelial cells (HUVECs) treated with ADSC-Exos, with miR-146a-5p highly expressed. MiR-146a-5p mimics enhanced the pro-angiogenic effects of ADSC-Exos, while inhibitors had the opposite effect. JAZF1 was identified as a direct downstream target of miR-146a-5p through bioinformatics, qRT-PCR, and dual luciferase assay. Overexpress of JAZF1 resulted in decreased proliferation, migration, and angiogenic capacity of HUVECs, and reduced VEGFA expression. This study proposes that ADSC-Exos regulate angiogenesis partly via the miR-146a-5p/JAZF1 axis.

Indexed as

Adipose TissueCo-Repressor ProteinsExosomesHuman Umbilical Vein Endothelial CellsMicroRNAsNeovascularization, PhysiologicAngiogenesisCell MovementCell ProliferationDiabetes MellitusDNA-Binding ProteinsHumansNeovascularization, PathologicStem CellsWound HealingCo-Repressor ProteinsDNA-Binding ProteinsJAZF1 protein, humanMicroRNAsMIRN146 microRNA, humanAdipose stem cellsAngiogenesisDiabetic woundExosomesJAZF1miR-146a-5p

Identifiers

PMID38393667
PMCPMC11087353
OpenAlexW4392109998

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.