Evidence map›Paper›PMID 38393637›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2024

Pharmacokinetic Study of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles HY-088 in Rats.

Xin Song, Minglan Zheng, Heping Hu, Lei Chen, Shuzhe Wang, Zhao Ding, Guangyi Fu, Luyao Sun, Liyuan Zhao, Ling Zhang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Xin SongSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230013, China.
Minglan ZhengYangtze River Delta Center for Drug Evaluation and Inspection of NMPA, Shanghai, 201210, China.
Heping HuSichuan Huiyu Seacross Pharmaceutical,. Co. Ltd, Sichaun, 610021, China.
Lei ChenInnoStar Bio-tech Nantong Co., Ltd., Nantong, 226133, China.
Shuzhe WangInnoStar Bio-tech Nantong Co., Ltd., Nantong, 226133, China.
Zhao DingSichuan Huiyu Seacross Pharmaceutical,. Co. Ltd, Sichaun, 610021, China.
Guangyi FuSichuan Huiyu Seacross Pharmaceutical,. Co. Ltd, Sichaun, 610021, China.
Luyao SunSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230013, China.
Liyuan ZhaoSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230013, China.
Ling ZhangInnoStar Bio-tech Nantong Co., Ltd., Nantong, 226133, China.
Bohua XuInnoStar Bio-tech Nantong Co., Ltd., Nantong, 226133, China. bhxu@innostar.cn.
Yunliang QiuChina State Institute of Pharmaceutical Industry, Shanghai InnorStar Biotech Co., Ltd., Shanghai, 201203, China. ylqiu@innostar.cn.
Anhui University of Traditional Chinese Medicine · CNNantong University · CNNational Medical Products Administration · CNShanghai Institute of Pharmaceutical Industry · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveHY-088 injection is an ultrasmall superparamagnetic iron oxide nanoparticle (USPIOs) composed of iron oxide crystals coated with polyacrylic acid (PAA) on the surface. The purpose of this study was to investigate the pharmacokinetics, tissue distribution, and mass balance of HY-088 injection.

methodsThe pharmacokinetics of [

resultsIn the pharmacokinetic study, [

conclusionsFollowing single intravenous administration of [

Indexed as

Magnetic Iron Oxide NanoparticlesRats, Sprague-DawleyAcrylic ResinsAnimalsDextransFemaleInjections, IntravenousMagnetite NanoparticlesMaleRatsTissue DistributionAcrylic Resinscarbopol 940DextransMagnetite Nanoparticles

Identifiers

PMID38393637
OpenAlexW4392105056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.