Evidence map›Paper›PMID 38393618›Full record

ArticleMolecular biology reports2024

The role of ApoE in fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions.

Hongyan Chen, Shaozhi Zhao, Qiang Jian, Yinfang Yan, Simin Wang, Xinwen Zhang, Yuqiang Ji

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
6.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hongyan ChenDepartment of Central Laboratory, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, No. 30, South Street, Beilin District, Xi'an, 710002, Shaanxi, China.
Shaozhi ZhaoCenter of Medical Genetics, Xi'an People's Hospital (Xi'an No. 4 Hospital), No. 21, Jiefang Road, Xi'an, 710004, Shaanxi, China.
Qiang JianCenter of Medical Genetics, Xi'an People's Hospital (Xi'an No. 4 Hospital), No. 21, Jiefang Road, Xi'an, 710004, Shaanxi, China.
Yinfang YanDepartment of Central Laboratory, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, No. 30, South Street, Beilin District, Xi'an, 710002, Shaanxi, China.
Simin WangDepartment of Central Laboratory, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, No. 30, South Street, Beilin District, Xi'an, 710002, Shaanxi, China.
Xinwen ZhangCenter of Medical Genetics, Xi'an People's Hospital (Xi'an No. 4 Hospital), No. 21, Jiefang Road, Xi'an, 710004, Shaanxi, China. xianxinwen@163.com.
Yuqiang JiDepartment of Central Laboratory, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, No. 30, South Street, Beilin District, Xi'an, 710002, Shaanxi, China. chenhongyan198607@163.com.
Northwest University · CN

Funding

Key Research and Development Plan Project of Shaanxi Province of China No.2021SF-151Science and Technology Planning Project of Xi'an No.21YXYJ0028Shaanxi Natural Science Basic Research Project No.2020JQ-958
6 · The paper itself

Abstract

backgroundThe aim of this study was to investigate whether ischemia/hypoxia conditions induce fatty acid transport from neurons to astrocytes and whether this mechanism is affected by ApoE isoforms. METHODS AND

resultsA neonatal rat model of hypoxic-ischemic brain damage was established. Excessive accumulation of lipid droplets and upregulation of ApoE expression occurred in the hippocampus and cerebral cortex after hypoxia-ischemia, which implied the occurrence of abnormal fatty acid metabolism. Lipid peroxidation was induced in an oxygen-glucose deprivation and reperfusion (OGDR) model of ApoE

conclusionsIn conclusion, ApoE plays an important role in mediating the transport of fatty acids from neurons to astrocytes under ischemia/hypoxia conditions, and this transport mechanism is ApoE isoform dependent. ApoE4 has a low transfer efficiency and may be a potential target for the clinical treatment of neonatal hypoxic-ischemic encephalopathy.

Indexed as

Apolipoprotein E4AstrocytesBoron CompoundsAnimalsFatty Acid-Binding ProteinsFatty AcidsHumansHypoxiaIschemiaNeuronsRats4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneApolipoprotein E4Boron CompoundsFatty Acid-Binding ProteinsFatty AcidsApoEAstrocyteFatty acid transportHypoxic-ischemic brain damageLipid dropletNeuron

Identifiers

PMID38393618
OpenAlexW4392096018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.