Evidence map›Paper›PMID 38393615›Full record

ReviewHead and neck pathology2024

Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets.

Talita de Carvalho Kimura, Reydson Alcides de Lima-Souza, Tayná Figueiredo Maciel, Luiz Paulo Kowalski, Cláudia Malheiros Coutinho-Camillo, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Talita de Carvalho KimuraDepartment of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil.
Reydson Alcides de Lima-SouzaDepartment of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil.
Tayná Figueiredo MacielDepartment of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, Brazil.
Luiz Paulo KowalskiDepartment of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
Cláudia Malheiros Coutinho-CamilloInternational Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.
Erika Said Abu EgalDepartment of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
Albina AltemaniDepartment of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
Fernanda Viviane MarianoDepartment of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil. fevimariano@gmail.com.ORCID http://orcid.org/0000-0003-3694-5025
Universidade Estadual de Campinas (UNICAMP) · BRAC Camargo Hospital · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalivary gland carcinomas (SGCs) are a rare group of malignant neoplasms of the head and neck region. MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been associated with the control biological process and oncogenic mechanism by the regulation of gene expression at the post-transcriptional level. Recent evidence has suggested that miRNA expression may play a role in the tumorigenesis and carcinogenesis process in SGCs.

methodsThis review provides a comprehensive literature review of the role of miRNAs expression in SGCs focusing on the diagnostic, prognostic, and therapeutic applications.

resultsIn this review, numerous dysregulated miRNAs have demonstrated an oncogenic and suppressor role in SGCs.

conclusionIn the future, these miRNAs may eventually constitute useful diagnostic and prognostic biomarkers that may lead to a better understanding of SGCs oncogenesis. Additionally, the development of therapeutic agents based on miRNAs may be a promising target in SGC treatment.

Indexed as

CarcinomaMicroRNAsSalivary Gland NeoplasmsBiomarkersBiomarkers, TumorCarcinogenesisCell Transformation, NeoplasticHumansPrognosisSalivary GlandsBiomarkersBiomarkers, TumorMicroRNAsDiagnosticMicroRNAsPrognosisSalivary gland neoplasmsTherapy

Identifiers

PMID38393615
PMCPMC10891027
OpenAlexW4392109770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.