Evidence map›Paper›PMID 38393498›Full record

ArticleJournal of fluorescence2025

Synthesis of Novel [{(2-Amino-5-Nitro-N-[(E)-Thiophen-2-yl-Methylidene]Aniline-κ

Sudarshan Pradhan, Pritika Gurung, Anmol Chettri, Uttam Kumar Singha, Prajal Chhetri, Tanmoy Dutta, Biswajit Sinha

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Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sudarshan PradhanDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Pritika GurungDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Anmol ChettriDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Uttam Kumar SinghaDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Prajal ChhetriDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India.
Tanmoy DuttaDepartment of Chemistry, JIS College of Engineering, Kalyani, 741235, India.
Biswajit SinhaDepartment of Chemistry, University of North Bengal, Darjeeling, 734013, India. biswachem@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel metal complex was synthesized using freshly prepared 2-Amino-5-nitro-N-[(E)-thiophen-2-yl-methylidene]aniline ligand with Zn (II) sulphate heptahydrate in a 1:1 molar ratio. The ligand and the complex were characterized using different spectroscopic techniques, and the complex was assigned a distorted square pyramidal geometry. Additionally, DNA binding assays and antibacterial activity were used to assess the biological perspectives for the synthesized complex, including the ligand and complex which was further confirmed by molecular docking. Fluorescence Spectroscopy, viscosity measurement, and adsorption measurement were used to investigate the interaction of the Zn (II) complex with CT-DNA. A comparative in vitro antibacterial activity study against Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, and Staphylococcus aureus strains were studied with free ligand and Zn (II) metal complex. The stable geometry of the complex was additionally established through computational simulation utilizing density functional theory, which was followed by the calculation of several electronic properties. The ADMET characteristics of the complex and ligand were also assessed using ADMET analysis. The in-silico ADMET properties pointed to a significant drug-likeness feature in the synthesized compounds, based on the Lipinski criteria.

Indexed as

Aniline CompoundsAnti-Bacterial AgentsCoordination ComplexesZincBacteriaDensity Functional TheoryDNAMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureAniline CompoundsAnti-Bacterial AgentsCoordination ComplexesDNAZincADMET propertiesAntibacterial activityDFTDNAMolecular dockingSchiff baseZn(II) complex

Identifiers

PMID38393498

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.