Evidence map›Paper›PMID 38393411›Full record

ArticleMedical oncology (Northwood, London, England)2024

Estrogen-related receptor alpha (ERRα) promotes the migration, invasion and angiogenesis of breast cancer stem cell-like cells.

Kartik Muduli, Jagannath Pradhan, Monica Prusty, Archana Priyadarshini Samal, K Sony Reddy, Selvakumar Elangovan

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The vitamin DFrontiers in immunology · 2025
    Review
  6. The Role of Estrogen across Multiple Disease Mechanisms.Current issues in molecular biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kartik MuduliSchool of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, 751024, India.ORCID http://orcid.org/0000-0002-4280-1194
Jagannath PradhanSchool of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, 751024, India.ORCID http://orcid.org/0009-0008-8055-1780
Monica PrustySchool of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, 751024, India.ORCID http://orcid.org/0000-0002-0472-2428
Archana Priyadarshini SamalSchool of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, 751024, India.ORCID http://orcid.org/0009-0005-9136-4348
K Sony ReddySchool of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, 751024, India.ORCID http://orcid.org/0000-0002-8437-5250
Selvakumar ElangovanSchool of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, 751024, India. selvakumar@kiitbiotech.ac.in.ORCID http://orcid.org/0000-0001-9906-5477
KIIT University · IN

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/INF/22/SP42155/2021Indian Council of Medical Research 45/30/2020-BIO/BMSScience and Engineering Research Board, DST, India EMR/2016/006964
6 · The paper itself

Abstract

Breast cancer progression, metastasis and recurrence are largely driven by breast cancer stem cells (BCSCs), which constitute a subset of tumor cells exhibiting stem cell characteristics. In this study, we evaluated the role of estrogen-related receptor alpha (ERRα) in the migration, invasion and angiogenesis of BCSCs. The inhibition of ERRα using XCT790 or knockdown of ERRα using shRNA inhibited the mammosphere formation efficiency, as well as the migration and invasion of BCSCs derived from the mammospheres of MCF7 and MDA-MB-231 (MB231) cells. Conversely, the overexpression of ERRα significantly increased the migration and invasion of BCSCs derived from the mammosphere. In addition, the XCT790 treatment or shERRα significantly downregulated the epithelial-mesenchymal transition (EMT), as evidenced by the downregulation in the expression of vimentin, Snail, Slug and N-cadherin in the mammospheres of MCF7 and MB231 cells. The chorioallantoic membrane assay showed that the conditioned media from XCT790-treated and shERRα cells significantly inhibited blood vessel formation and vessel length. Furthermore, XCT790 treatment or shERRα also downregulated the expression of molecular markers of angiogenesis, such as VEGF-A and Ang-2 in the mammospheres. Conversely, the overexpression of ERRα in MCF7 cells significantly increased both EMT and angiogenesis. These findings suggest that ERRα inhibits the migration, invasion and angiogenesis of BCSCs, suggesting as a potential target for breast cancer therapy.

Indexed as

Breast NeoplasmsERRalpha Estrogen-Related ReceptorNitrilesThiazolesAngiogenesisCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionFemaleHumansNeoplastic Stem CellsReceptors, EstrogenERRalpha Estrogen-Related ReceptorESRRA protein, humanNitrilesReceptors, EstrogenThiazolesXCT790Breast cancerCancer stem cellsEstrogen-related receptor αInvasionMigrationXCT790

Identifiers

PMID38393411
OpenAlexW4392125783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.