Evidence map›Paper›PMID 38393346›Full record

ArticleActa diabetologica2024

Association of carotid atherosclerosis markers with all-cause and cardiovascular disease-specific mortality in persons with type 2 diabetes: a causal mediation analysis with glucose variation.

Cheng-Chieh Lin, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li

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Article in Acta diabetologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cheng-Chieh Lin *School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Chia-Ing Li *School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Chiu-Shong LiuSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Chih-Hsueh LinSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Shing-Yu YangDepartment of Public Health, College of Public Health, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., 406040, Taichung, Taiwan, R.O.C.
Tsai-Chung LiDepartment of Public Health, College of Public Health, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., 406040, Taichung, Taiwan, R.O.C.. tcli@mail.cmu.edu.tw.ORCID http://orcid.org/0000-0002-3346-7462
China Medical University · TWAsia University · TW

Funding

China Medical University CMU112-MF-80Ministry of Science and Technology, Taiwan MOST 109-2314-B-039-031-MY2Ministry of Science and Technology, Taiwan MOST 110-2314-B-039-021-Ministry of Science and Technology, Taiwan MOST 111-2314-B-039-018-National Science and Technology Council NSTC 112-2314-B-039-042-
6 · The paper itself

Abstract

aimsGlucose variation (GV) is independently associated with mortality in patients with diabetes. However, no study has examined the effects of carotid atherosclerosis markers on mortality after considering GV. Our purpose is to investigate the independent effects of carotid atherosclerosis markers in persons with type 2 diabetes (T2DM) after considering GV and the mediation effects of carotid atherosclerosis markers on associations between GV with cardiovascular disease (CVD) mortality. MATERIALS AND

methodsThis study is a retrospective cohort study including 3628 persons with T2DM who were admitted to a medical center between January 01, 2001 and October 31, 2021. GV was defined as a coefficient of variation (CV) of repeated measurements within a year before the index date (date of first IMT assessment). Carotid atherosclerosis markers included intima-media thickness (IMT), plaque, and stenosis. The outcomes consisted of all-cause and expanded cardiovascular disease (CVD) mortality. Cox proportional hazards models were applied.

resultsAmong the participants, 286 (7.9%) had IMT ≥ 2 mm, 2834 (78.1%) had carotid plaque, and 464 (12.8%) had carotid stenosis ≥ 50%. When GV was considered, IMT, carotid plaque, and carotid stenosis were significant factors for all-cause mortality (except IMT considering HbA1c-CV) and expanded CVD mortality. IMT was a significant mediator in the associations of fasting plasma glucose (FPG)-CV with all-cause and expanded CVD mortality (2 and 3.19%, respectively), and carotid stenosis was a significant mediator in the association between FPG-CV and expanded CVD mortality (3.83%).

conclusionsOur statistical evaluations show suggests that carotid atherosclerosis markers are important predictors of CVD mortality in persons with T2DM if GV is considered. In addition, IMT and carotid stenosis were significant mediators in the association between GV and mortality.

Indexed as

Blood GlucoseCardiovascular DiseasesCarotid Artery DiseasesCarotid Intima-Media ThicknessDiabetes Mellitus, Type 2Mediation AnalysisAgedBiomarkersFemaleHumansMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesRisk FactorsBiomarkersBlood GlucoseIntima-media thicknessMortalityType 2 diabetes

Identifiers

PMID38393346
OpenAlexW4392096636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.