Evidence map›Paper›PMID 38393133›Full record

ArticleTropical medicine and infectious disease2024

Serological Comparison of Native Antigen ELISAs with Rapid ICT Test Kits for the Diagnosis of Human Alveolar and Cystic Echinococcosis in China.

Shu-Kun Yang, Wei Zhang, Na Zhu, Donald P McManus, Darren J Gray, Archie C A Clements, Angela M Cadavid Restrepo, Gail M Williams, Ting Zhang, Guo-Rong Ma and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and infectious disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Partially purifiedMicrobiology spectrum · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Shu-Kun YangDepartment of Radiology, The Second Affiliated Hospital of Ningxia Medical University, The First People's Hospital of Yinchuan City, Yinchuan 750001, China.
Wei ZhangDepartment of Pathogenic Biology & Medical Immunology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
Na ZhuDepartment of Pathogenic Biology & Medical Immunology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
Donald P McManusMolecular Parasitology Laboratory, Global Health & Tropical Medicine, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Darren J GrayMolecular Parasitology Laboratory, Global Health & Tropical Medicine, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Archie C A ClementsDepartment of Global Health, Research School of Population Health, Australian National University, Acton, ACT 2600, Australia.
Angela M Cadavid RestrepoInfectious Disease Epidemiology Unit, School of Public Health, University of Queensland, Brisbane, QLD 4006, Australia.
Gail M WilliamsInfectious Disease Epidemiology Unit, School of Public Health, University of Queensland, Brisbane, QLD 4006, Australia.
Ting ZhangNHC Key Laboratory of Parasite and Vector Biology, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), Shanghai 200025, China.ORCID 0000-0001-7383-5090
Guo-Rong MaDepartment of Pathogenic Biology & Medical Immunology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
Yan-Hui YangDepartment of Pathogenic Biology & Medical Immunology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
Yu-Rong YangDepartment of Pathogenic Biology & Medical Immunology, School of Basic Medical Science, Ningxia Medical University, Yinchuan 750004, China.
Ningxia Medical University · CNAustralian National University · AUThe University of Queensland · AUNational Institute for Parasitic Diseases · CNQIMR Berghofer Medical Research Institute · AUYinchuan First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to compare the diagnostic performance of native antigen ELISAs and ADAMU-AE/CE commercial ICT test kits in subjects either exposed to

methodsA total of 370 subjects with a previous clinical confirmation of CE or AE from northwestern China were recruited. Serum samples were also obtained from 3923 children/teenagers during a community survey. All sera were tested using native antigen ELISAs. The ADAMU-AE/CE test kits were subsequently used for the serology of the 370 clinically confirmed individuals and of 251 children/teenagers that were ELISA antibody-positive for both

findingsThere was poor consistency (Kappa = 0.26 and 0.28 for AE and CE respectively) between the native antigen ELISAs and the ADAMU kits for the diagnosis of AE and CE among the cases and the surveyed children/teenagers, but a relatively good consistency (Kappa = 0.63) between the ADAMU-AE kit and ultrasound observations for the AE cases. Additionally, of the 251 teenagers co-positive for both AE and CE antibodies by the native antigen ELISAs, only one was found positive by the ADAMU-AE kit, verified as a new AE case on subsequent ultrasound follow-up. The remainder (N = 250) were negative by serology using the ADAMU-AE/CE kits and by ultrasound examination. The two native antigen ELISAs did not discriminate well between cases of clinically diagnosed AE and CE. In contrast, ADAMU-AE and ADAMU-CE commercial ICT test kits readily differentiated cases of AE from CE with specificities of 99% for AE and 100% for CE.

conclusionsThe ADAMU-AE/CE kits proved reliable, accurate, and amenable diagnostic tools in the clinical setting for confirmation of suspected AE/CE cases. The native antigen ELISAs tests can provide useful information on the level of human exposure to

Indexed as

ADAMU-AE/CE kitsalveolar echinococcosiscystic echinococcosisegg exposure of Echinococcus granulosus and E. multilocularisnative antigen ELISAsserological diagnosis

Identifiers

PMID38393133
PMCPMC10893119
OpenAlexW4391602954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.