ArticleTropical medicine and infectious disease2024
The Spatiotemporal Distribution and Molecular Characterization of Circulating Dengue Virus Serotypes/Genotypes in Senegal from 2019 to 2023.
Article in Tropical medicine and infectious disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 7 citations in OpenAlex.
- Evaluating myxovirus resistance protein A-based rapid testing combined with pathogen sequencing for arboviral and incidental viral infection surveillance in Senegal.Microbiology spectrum · 2026Article
- Study of patients with acute undifferentiated fever identifies dengue as a growing threat to public health in Mali.PLoS neglected tropical diseases · 2026Article
- External quality assurance of molecular serotype detection of dengue virus RNA among virus research and diagnostic laboratories in India.Frontiers in cellular and infection microbiology · 2026Article
- Insecticide resistance in Aedes aegypti and Aedes albopictus in southern Benin: quantification, investigation of kdr mutations, and detection of detoxification enzyme activity.Tropical medicine and health · 2025Article
- Dengue diagnosis in Guinea in two returning travelers from Côte d'Ivoire: a case report.IJID regions · 2025Article
- CDC dengue typing kit fails to detect dengue virus 2 sylvatic genotype.Journal of clinical microbiology · 2025Article
- Spatial patterns and clustering of dengue incidence in Mexico: Analysis of Moran's index across 2,471 municipalities from 2022 to 2024.PloS one · 2025Article
- A new lineage nomenclature to aid genomic surveillance of dengue virus.medRxiv : the preprint server for health sciences · 2024Article
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Authors and funding
17 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Dengue virus is becoming a major public health threat worldwide, principally in Africa. From 2016 to 2020, 23 outbreaks were reported in Africa, principally in West Africa. In Senegal, dengue outbreaks have been reported yearly since 2017. Data about the circulating serotypes and their spatial and temporal distribution were limited to outbreaks that occurred between 2017 and 2018. Herein, we describe up-to-date molecular surveillance of circulating DENV serotypes in Senegal between 2019 to 2023 and their temporal and spatial distribution around the country. For this purpose, suspected DENV-positive samples were collected and subjected to dengue detection and serotyping using RT-qPCR methods. Positive samples were used for temporal and spatial mapping. A subset of DENV+ samples were then sequenced and subjected to phylogenetic analysis. Results show a co-circulation of three DENV serotypes with an overall predominance of DENV-3. In terms of abundance, DENV-3 is followed by DENV-1, with scarce cases of DENV-2 from February 2019 to February 2022. Interestingly, data show the extinction of both serotype 1 and serotype 2 and the only circulation of DENV-3 from March 2022 to February 2023. At the genotype level, the analysis shows that sequenced strains belong to same genotype as previously described: Senegalese DENV-1 strains belong to genotype V, DENV-2 strains to the cosmopolitan genotype, and DENV-3 strains to Genotype III. Interestingly, newly obtained DENV 1-3 sequences clustered in different clades within genotypes. This co-circulation of strains belonging to different clades could have an effect on virus epidemiology and transmission dynamics. Overall, our results highlight DENV serotype replacement by DENV-3, accompanied by a wider geographic distribution, in Senegal. These results highlight the importance of virus genomic surveillance and call for further viral fitness studies using both in vitro and in vivo models, as well as in-depth phylogeographic studies to uncover the virus dispersal patterns across the country.
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