Evidence map›Paper›PMID 38393024›Full record

ArticleMarine drugs2024

Comparative Evaluation of the Antibacterial and Antitumor Activities of 9-Phenylfascaplysin and Its Analogs.

Maxim E Zhidkov, Maria A Sidorova, Polina A Smirnova, Oleg A Tryapkin, Andrey V Kachanov, Alexey V Kantemirov, Lyubov G Dezhenkova, Natalia E Grammatikova, Elena B Isakova, Andrey E Shchekotikhin and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. A Spin-Labeled Derivative of Gossypol.Molecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Maxim E ZhidkovDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.
Maria A SidorovaDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.
Polina A SmirnovaDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.ORCID 0000-0002-2627-5227
Oleg A TryapkinDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.ORCID 0000-0001-8732-0055
Andrey V KachanovDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.
Alexey V KantemirovDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.ORCID 0000-0002-8982-5126
Lyubov G DezhenkovaLaboratory of Chemical Transformation of Antibiotics, Gause Institute of New Antibiotics, 119021 Moscow, Russia.
Natalia E GrammatikovaLaboratory of Chemical Transformation of Antibiotics, Gause Institute of New Antibiotics, 119021 Moscow, Russia.
Elena B IsakovaLaboratory of Chemical Transformation of Antibiotics, Gause Institute of New Antibiotics, 119021 Moscow, Russia.
Andrey E ShchekotikhinLaboratory of Chemical Transformation of Antibiotics, Gause Institute of New Antibiotics, 119021 Moscow, Russia.ORCID 0000-0002-6595-0811
Marina A PakDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.
Olga N StyshovaDepartments of Biotechnology and Marine Natural Compounds Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of The Russian Academy of Sciences, 690922 Vladivostok, Russia.
Anna A KlimovichDepartments of Biotechnology and Marine Natural Compounds Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of The Russian Academy of Sciences, 690922 Vladivostok, Russia.
Aleksandr M PopovDepartments of Biotechnology and Marine Natural Compounds Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of The Russian Academy of Sciences, 690922 Vladivostok, Russia.
Far Eastern Federal University · RUGause Institute of New Antibiotics Russian Academy of Medical Sciences · RUPacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RU

Funding

Far Eastern Federal University Program FEFU Priority 2030: Physics and Materials ScienceRussian Foundation for Basic Research 20-33-90128the Ministry of Science and Higher Education of the Russian Federation 075-03-2022-114/7 (project FZNS- 2022-0014)
6 · The paper itself

Abstract

Based on the results of our own preliminary studies, the derivative of the marine alkaloid fascaplysin containing a phenyl substituent at C-9 was selected to evaluate the therapeutic potential in vivo and in vitro. It was shown that this compound has outstandingly high antimicrobial activity against Gram-positive bacteria, including antibiotic-resistant strains in vitro. The presence of a substituent at C-9 of the framework is of fundamental importance, since its replacement to neighboring positions leads to a sharp decrease in the selectivity of the antibacterial action, which indicates the presence of a specific therapeutic target in bacterial cells. On a model of the acute bacterial sepsis in mice, it was shown that the lead compound was more effective than the reference antibiotic vancomycin seven out of nine times. However, ED

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsCarbolinesIndolizinesQuaternary Ammonium CompoundsAnimalsIndolesMiceMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial AgentsAnti-Infective AgentsCarbolinesfascaplysineIndolesIndolizinesQuaternary Ammonium Compounds9-phenylfascaplysinantibacterial activityantiproliferative activityantitumor activityfascaplysin derivatives

Identifiers

PMID38393024
PMCPMC10890213
OpenAlexW4391169636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.