Evidence map›Paper›PMID 38392844›Full record

ArticlePathogens (Basel, Switzerland)2024

The NLRP3 Inflammasome Is Dispensable in Methicillin-Resistant

Santosh Paudel, Rahul Kumar, Kenneth A Rogers, Yogesh Saini, Sonika Patial, Ritwij Kulkarni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Santosh PaudelDepartment of Biology, University of Louisiana at Lafayette, Lafayette, LA 70504, USA.ORCID 0000-0002-5266-391X
Rahul KumarDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.ORCID 0000-0002-5677-3999
Kenneth A RogersNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, LA 70560, USA.
Yogesh SainiDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
Sonika PatialNational Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, Durham, NC 27709, USA.
Ritwij KulkarniDepartment of Biology, University of Louisiana at Lafayette, Lafayette, LA 70504, USA.
University of Louisiana at Lafayette · USNorth Carolina State University · USNational Institute of Environmental Health Sciences · US

Funding

Understanding the pathophysiology of GBS UTI in diabetesR21AI165939 · NIAID · UNIVERSITY OF LOUISIANA AT LAFAYETTE · PI KULKARNI, RITWIJ · 2021 to 2022
$381k
NIAID NIH HHS R21 AI165939NIH HHS R21AI165939
6 · The paper itself

Abstract

The NLRP3 inflammasome is a cytoplasmic complex that senses molecular patterns from pathogens or damaged cells to trigger an innate immune defense response marked by the production of proinflammatory cytokines IL-1β and IL-18 and an inflammatory death called pyroptosis. The NLRP3 inflammasome is activated in the urinary tract by a variety of infectious and non-infectious insults. In this study, we investigated the role of the NLRP3 inflammasome by comparing the pathophysiology of methicillin-resistant

Indexed as

InflammasomesMethicillin-Resistant Staphylococcus aureusMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinStaphylococcal InfectionsUrinary Tract InfectionsAnimalsCytokinesDisease Models, AnimalFemaleMiceMice, Inbred C57BLCytokinesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseinflammasomeMRSANLRP3UTI

Identifiers

PMID38392844
PMCPMC10893321
OpenAlexW4391229264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.