Activity of the Di-Substituted Urea-Derived Compound I-17 in
José Vitorino Dos Santos, Jorge Mansur Medina, Karina Luiza Dias Teixeira, Daniel Marcos Julio Agostinho, Michael Chorev, Aurora Diotallevi, Luca Galluzzi, Bertal Huseyin Aktas, Ulisses Gazos Lopes
Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 4 institutions in 3 countries.
José Vitorino Dos SantosLaboratory of Molecular Parasitology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil.
Jorge Mansur MedinaLaboratory of Molecular Parasitology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil.
Karina Luiza Dias TeixeiraDepartment of Cell Biology, University of Virginia, Pinn Hall, Charlottesville, VA 22908, USA.
Daniel Marcos Julio AgostinhoLaboratory of Molecular Parasitology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil.
Michael ChorevDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Aurora DiotalleviDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.ORCID 0000-0001-5456-1821
Luca GalluzziDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.ORCID 0000-0002-1747-526X
Bertal Huseyin AktasDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ulisses Gazos LopesLaboratory of Molecular Parasitology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil.
Universidade Federal do Rio de Janeiro · BRBrigham and Women's Hospital · USUniversity of Urbino · ITUniversity of Virginia · US
Funding
Targeting Endoplasmic Reticulum Stress Response for Cancer TherapyR01CA152312 · NCI · HARVARD MEDICAL SCHOOL · PI AKTAS, BERTAL H. · 2011 to 2015
$1.8M
Protein Synthesis Inhibitors as anti-T. Cruzi agentsR21AI154196 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI AKTAS, BERTAL H. · 2020 to 2021
Protein synthesis has been a very rich target for developing drugs to control prokaryotic and eukaryotic pathogens. Despite the development of new drug formulations, treating human cutaneous and visceral
Indexed as
Antiprotozoal AgentsLeishmaniaMacrophagesUreaAnimalsHumansLeishmaniasisMiceNitric OxideNitric Oxide Synthase Type IIAntiprotozoal AgentsNitric OxideNitric Oxide Synthase Type IIUreadi-substituted urea-derivativeseIF2αeIF2α kinase activatorsLeishmaniasistranslation initiation
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Activity of the Di-Substituted Urea-Derived Compound I-17 in · full record | OpenQuestion