ArticleJournal of fungi (Basel, Switzerland)2024
Clinical Diagnosis and Laboratory Testing of Abnormal Appearing Toenails: A Retrospective Assessment of Confirmatory Testing for Onychomycosis in the United States, 2022-2023.
Article in Journal of fungi (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Comparative evaluation of conventional and nanopore approaches in onychomycosis diagnosis.Diagnostic microbiology and infectious disease · 2026Article
- Schiff base metal complexes as emerging therapeutics against antimicrobial-resistant skin pathogens.ADMET & DMPK · 2026Review
- Prevalence and diversity of antifungal resistance inAntimicrobial agents and chemotherapy · 2025Article
- Specific Primers and Nested PCR FindJournal of fungi (Basel, Switzerland) · 2025Article
- The Dual PathogenJournal of fungi (Basel, Switzerland) · 2025Review
- Analysis of Causative Factors and Potential Predictors of Onychomycosis: A Retrospective Single-Center Study in Poland.Journal of fungi (Basel, Switzerland) · 2025Article
- Patient Characteristics, Diagnostic Testing Utilization, and Antifungal Prescribing Pattern for Onychomycosis in the USA: A Cohort Study Using DataDerm, 2016-2022.Skin appendage disorders · 2025Article
- Dermoscopy-guided sampling improves the diagnostic yield of fungal culture for onychomycosis: a comparative study.Frontiers in medicine · 2025Article
- Epidemiological trends and healthcare disparities in onychomycosis: An analysis of the All of Us research program.PloS one · 2025Article
- Biofilm Formation in Clinical Isolates ofJournal of fungi (Basel, Switzerland) · 2024Article
- Epidemiology of Onychomycosis in the United States Characterized Using Molecular Methods, 2015-2024.Journal of fungi (Basel, Switzerland) · 2024Article
- Tinea pedis, peripheral vascular disease, and male gender are associated with higher odds of onychomycosis in a retrospective case-control study of 1257 onychodystrophy patients.Journal of the American Academy of Dermatology · 2024Article
- Onychomycosis in Foot and Toe Malformations.Journal of fungi (Basel, Switzerland) · 2024Article
- Diagnosis and management of tinea infections.American family physician · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Onychomycosis is an under-recognized healthcare burden. Despite the risk of misdiagnosis, confirmatory laboratory testing is under-utilized. Histopathologic examination with polymerase chain reaction (PCR) is currently the most effective diagnostic method; it offers direct detection and identification of a fungal invasion. In this retrospective cohort study, we assessed confirmatory testing results, with matching clinical diagnoses, in 96,293 nail specimens submitted during a 9-month period from 2022 to 2023. Toenail specimens were examined using fungal culture, histopathology and/or PCR. Clinical diagnoses were identified using the International Classification of Diseases 10th Revision codes. For clinically diagnosed onychomycosis patients, the overall positivity rate was 59.4%; a similar positivity rate (59.5%) was found in patients with clinically diagnosed non-fungal nail dystrophy. Performing a histopathologic examination with PCR was more likely to provide pathogen identification results than using fungal culture. Male patients had a higher rate of onychomycosis overall; however, female patients had more non-dermatophyte mold onychomycosis caused by
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