Evidence map›Paper›PMID 38392648›Full record

ArticleJournal of personalized medicine2024

Performance in Behavioral Testing in an Animal Model of Post-Surgical Hypoparathyroidism.

Cristina Dettori, Francesca Ronca, Giulia Di Buono, Alessandro Saba, Francesca Di Lupo, Beatrice Polini, Caterina Ricardi, Sabina Frascarelli, Filomena Cetani, Claudio Marcocci and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Cristina DettoriDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.
Francesca RoncaDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.
Giulia Di BuonoDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.
Alessandro SabaDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.ORCID 0000-0003-0611-5549
Francesca Di LupoDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.
Beatrice PoliniDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.ORCID 0000-0002-2664-6091
Caterina RicardiDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.
Sabina FrascarelliDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.
Filomena CetaniEndocrine Unit, University Hospital of Pisa, 56124 Pisa, Italy.
Claudio MarcocciEndocrine Unit, University Hospital of Pisa, 56124 Pisa, Italy.
Riccardo ZucchiDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.
Grazia ChielliniDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.ORCID 0000-0001-6703-5820
Marco ScaleseInstitute of Clinical Physiology, National Council of Research, 56126 Pisa, Italy.ORCID 0000-0002-7470-2422
Federica SaponaroDepartment of Surgical, Medical and Molecular Pathology and Critical Care, 56126 Pisa, Italy.ORCID 0000-0002-0277-1648
Azienda Ospedaliera Universitaria Pisana · ITIstituto di Fisiologia Clinica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoparathyroidism (HypoPT) is characterized by hypocalcemia and undetectable/inappropriately low PTH. Post-surgical HypoPT (PS-HypoPT) is the most common cause. Patients with PS-HypoPT present neuropsychological symptoms, probably due to the PTH deprivation in the central nervous system (CNS). However, these mechanisms are still not elucidated. The aim of this study was to evaluate the effects of PTH deprivation on CNS in an animal model of PS-HypoPT via a cognitive/behavioral assessment approach.

methodsA surgical rat model of PS-HypoPT was obtained and treated with calcium to maintain normocalcemia. Twenty PS-HypoPT rats and twenty sham-operated controls (Crl) underwent behavioral testing in a Morris Water Maze (MWM), Open Field (OF), and Elevated Plus Maze (EPM).

resultsIn the MWM, PTx rats showed a higher Escape Latency Time compared to Crl rats (

conclusionsThis animal model of PS-HypoPT shows an impairment in spatial memory, which improved after training, and a marked anxiety-like behavior, resembling the condition of patients with PS-HypoPT. Further studies are needed to elucidate mechanisms.

Indexed as

hypoparathyroidismpost-surgical hypoparathyroidismPTH

Identifiers

PMID38392648
PMCPMC10890136
OpenAlexW4391942935

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.