Evidence map›Paper›PMID 38392627›Full record

ArticleJournal of personalized medicine2024

Influence of Tumor Stroma on the Aggressiveness of Poorly Cohesive Gastric Carcinoma.

Giorgio Malpeli, Federica Filippini, Fabrizio Tedone, Lorena Torroni, Mariella Alloggio, Claudia Castelli, Mariagiulia Dal Cero, Roberto Perris, Anna Tomezzoli, Giovanni De Manzoni and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Giorgio MalpeliDepartment of Human Sciences for the Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Roma, Italy.ORCID 0000-0002-2996-2903
Federica FilippiniUnit of General and Upper GI Surgery, University of Verona, 37126 Verona, Italy.
Fabrizio TedoneUnit of General and Upper GI Surgery, University of Verona, 37126 Verona, Italy.
Lorena TorroniUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37126 Verona, Italy.ORCID 0000-0002-0707-7153
Mariella AlloggioUnit of General and Upper GI Surgery, University of Verona, 37126 Verona, Italy.
Claudia CastelliDepartment of Pathology, Verona University Hospital, 37126 Verona, Italy.
Mariagiulia Dal CeroSection of Gastrointestinal Surgery, Hospital del Mar Medical Research Institute (IMIM), Universitat Autònoma de Barcelona, 08003 Barcelona, Spain.
Roberto PerrisCentre for Molecular and Translational Oncology (COMT), University of Parma, 43121 Parma, Italy.
Anna TomezzoliDepartment of Pathology, Verona University Hospital, 37126 Verona, Italy.
Giovanni De ManzoniUnit of General and Upper GI Surgery, University of Verona, 37126 Verona, Italy.
Maria BencivengaUnit of General and Upper GI Surgery, University of Verona, 37126 Verona, Italy.
University of Verona · ITUniversitat Autònoma de Barcelona · ESUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-stroma crosstalk promotes the adaptation of cancer cells to the local microenvironment and sustains their growth. We assessed the quantitative and qualitative impact of intralesional stroma on clinic-pathological features and the prognosis of poorly cohesive gastric cancer (PCGC) variants. Tissue microarrays including 75 PCGC specimens were immunostained for cytokeratin 8/18 and α-smooth muscle actin to assess the relative proportion of neoplastic cells versus stromal components and the cases were subsequently divided into stroma-rich (SR) and stroma-poor (SP) tumors. Stromal status is significantly associated with the depth of tumor invasion. Patient survival rate was found to be higher in the SP compared to the SR tumor group and, hence, abundant stroma was identified as a significant risk factor in univariable analysis but had no independent prognostic impact. We also investigated the mRNA levels of KRT8 and the associated transcriptional signatures using the molecular data of 82 PCGC cases divided into KRT8-high and KRT8-low groups. KRT8-high tumors were enriched in proteins localized in the extracellular compartment and their expression levels correlated with longer survival in the KRT8-high group and shorter overall survival in the KRT8-low group. Comprehensively, we find that relative intralesional stromal content is a marker of aggressiveness in PCGC tumors and that extracellular proteins characterize functionally and clinically different PCGC subgroups.

Indexed as

diffuse typegastric cancerintratumoral stromapoorly cohesive

Identifiers

PMID38392627
PMCPMC10890005
OpenAlexW4391679654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.