Evidence map›Paper›PMID 38392596›Full record

ArticleJournal of personalized medicine2024

Prevention of Protease-Induced Degradation of Desmoplakin via Small Molecule Binding.

Isabel M Romov, Roujon A Nowzari, Clay P Page, Madeleine R Benes, Maegen A Borzok, Nathan T Wright

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Isabel M RomovDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.ORCID 0000-0002-6524-348X
Roujon A NowzariDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.
Clay P PageDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.
Madeleine R BenesDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.
Maegen A BorzokDepartment of Biochemistry, Chemistry, Engineering and Physics, Commonwealth University of Pennsylvania, Mansfield, PA 16933, USA.
Nathan T WrightDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.
James Madison University · USMansfield University · US

Funding

Exploration of Novel Strategies to Preserve Desmoplakin Variant FunctionR15GM148890 · NIGMS · JAMES MADISON UNIVERSITY · PI WRIGHT, NATHAN THOMPSON · 2022 to 2024
$528k
NIGMS NIH HHS R15 GM148890NIH HHS R15GM148890
6 · The paper itself

Abstract

Desmoplakin (DSP) is a large (~260 kDa) protein found in the desmosome, the subcellular structure that links the intermediate filament network of one cell to its neighbor. A mutation "hot-spot" within the NH

Indexed as

arrhythmogenic cardiomyopathycalpaindesmoplakindrug screening

Identifiers

PMID38392596
PMCPMC10890502
OpenAlexW4391404417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.