Evidence map›Paper›PMID 38392323›Full record

ReviewBiology2024

The Intrinsic Cardiac Nervous System: From Pathophysiology to Therapeutic Implications.

Giuseppe Giannino, Valentina Braia, Carola Griffith Brookles, Federico Giacobbe, Fabrizio D'Ascenzo, Filippo Angelini, Andrea Saglietto, Gaetano Maria De Ferrari, Veronica Dusi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giuseppe GianninoCardiology, Department of Medical Sciences, University of Turin, 10124 Torino, Italy.ORCID 0000-0002-3825-6867
Valentina BraiaCardiology, Department of Medical Sciences, University of Turin, 10124 Torino, Italy.
Carola Griffith BrooklesCardiology, Department of Medical Sciences, University of Turin, 10124 Torino, Italy.
Federico GiacobbeCardiology, Department of Medical Sciences, University of Turin, 10124 Torino, Italy.ORCID 0000-0002-1176-4300
Fabrizio D'AscenzoCardiology, Department of Medical Sciences, University of Turin, 10124 Torino, Italy.ORCID 0000-0002-6646-9317
Filippo AngeliniDivision of Cardiology, Cardiovascular and Thoracic Department, 'Città della Salute e della Scienza' Hospital, 10126 Torino, Italy.ORCID 0000-0003-4711-0891
Andrea SagliettoDivision of Cardiology, Cardiovascular and Thoracic Department, 'Città della Salute e della Scienza' Hospital, 10126 Torino, Italy.ORCID 0000-0001-9475-1507
Gaetano Maria De FerrariCardiology, Department of Medical Sciences, University of Turin, 10124 Torino, Italy.ORCID 0000-0003-4940-0876
Veronica DusiCardiology, Department of Medical Sciences, University of Turin, 10124 Torino, Italy.ORCID 0000-0002-2290-3126
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cardiac autonomic nervous system (CANS) plays a pivotal role in cardiac homeostasis as well as in cardiac pathology. The first level of cardiac autonomic control, the intrinsic cardiac nervous system (ICNS), is located within the epicardial fat pads and is physically organized in ganglionated plexi (GPs). The ICNS system does not only contain parasympathetic cardiac efferent neurons, as long believed, but also afferent neurons and local circuit neurons. Thanks to its high degree of connectivity, combined with neuronal plasticity and memory capacity, the ICNS allows for a beat-to-beat control of all cardiac functions and responses as well as integration with extracardiac and higher centers for longer-term cardiovascular reflexes. The present review provides a detailed overview of the current knowledge of the bidirectional connection between the ICNS and the most studied cardiac pathologies/conditions (myocardial infarction, heart failure, arrhythmias and heart transplant) and the potential therapeutic implications. Indeed, GP modulation with efferent activity inhibition, differently achieved, has been studied for atrial fibrillation and functional bradyarrhythmias, while GP modulation with efferent activity stimulation has been evaluated for myocardial infarction, heart failure and ventricular arrhythmias. Electrical therapy has the unique potential to allow for both kinds of ICNS modulation while preserving the anatomical integrity of the system.

Indexed as

cardiac autonomic nervous systemcardioneuroablationganglionated plexi ablationintrinsic cardiac nervous systemneuromodulation

Identifiers

PMID38392323
PMCPMC10887082
OpenAlexW4391616468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.