Evidence map›Paper›PMID 38392016›Full record

ReviewBiosensors2024

Current Trends in RNA Virus Detection via Nucleic Acid Isothermal Amplification-Based Platforms.

Le Thi Nhu Ngoc, Young-Chul Lee

Open access · goldAbstract readReview
In one paragraph

Review in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Point of Care Testing and Recombinase Polymerase Amplification.Journal of clinical laboratory analysis · 2026
    Article
  2. Review
  3. Integrating metagenomics and metatranscriptomics intoThe Journal of general virology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Light-up RNA aptamer-based T-NASBA: a one-pot, label-free strategy for miRNA detection.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Multicomponent DNA Nanomachines for Amplification-Free Viral RNA Detection.International journal of molecular sciences · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Le Thi Nhu NgocDepartment of Nano Science and Technology Convergence, Gachon University, 1342 Seongnam-Daero, Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Republic of Korea.
Young-Chul LeeDepartment of BioNano Technology, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Republic of Korea.ORCID 0000-0002-4702-0282
Gachon University · KR

Funding

Basic Science Research Capacity Enhancement Project through a Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education 2019R1A6C1010016Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education 2021R1F1A1047906
6 · The paper itself

Abstract

Ribonucleic acid (RNA) viruses are one of the major classes of pathogens that cause human diseases. The conventional method to detect RNA viruses is real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), but it has some limitations. It is expensive and time-consuming, with infrastructure and trained personnel requirements. Its high throughput requires sophisticated automation and large-scale infrastructure. Isothermal amplification methods have been explored as an alternative to address these challenges. These methods are rapid, user-friendly, low-cost, can be performed in less specialized settings, and are highly accurate for detecting RNA viruses. Microfluidic technology provides an ideal platform for performing virus diagnostic tests, including sample preparation, immunoassays, and nucleic acid-based assays. Among these techniques, nucleic acid isothermal amplification methods have been widely integrated with microfluidic platforms for RNA virus detection owing to their simplicity, sensitivity, selectivity, and short analysis time. This review summarizes some common isothermal amplification methods for RNA viruses. It also describes commercialized devices and kits that use isothermal amplification techniques for SARS-CoV-2 detection. Furthermore, the most recent applications of isothermal amplification-based microfluidic platforms for RNA virus detection are discussed in this article.

Indexed as

Nucleic AcidsVirusesHumansMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesReverse TranscriptionSARS-CoV-2Sensitivity and SpecificityNucleic Acidsloop-mediated isothermal amplification (LAMP)nucleic acid sequence-based amplification (NASBA)point-of-care testing (POCT)recombinase-aided amplification (RAA)recombinase polymerase amplification (RPA)RNA virus detection

Identifiers

PMID38392016
PMCPMC10886876
OpenAlexW4391746496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.