Evidence map›Paper›PMID 38391999›Full record

ReviewBiosensors2024

Recent Advances in Real-Time Label-Free Detection of Small Molecules.

Andy Chieng, Zijian Wan, Shaopeng Wang

Abstract readReview
In one paragraph

Review in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
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  9. Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andy ChiengCenter for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Zijian WanCenter for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Shaopeng WangCenter for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-2680-0503

Funding

Critical angle reflection imaging for label-free quantification of molecular interactionsR42GM143986 · NIGMS · BIOSENSING INSTRUMENT, INC. · PI LY, NGUYEN · 2021 to 2023
$2.2M
Development of a charge-sensitive optical detection system for high-throughput study of small moleculesR44GM139535 · NIGMS · BIOSENSING INSTRUMENT, INC. · PI LY, NGUYEN · 2021 to 2022
$1.7M
A Virion-Display Oscillator Array and Detection Platform for Quantification of Transmembrane Protein Binding KineticsR33CA235294 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WANG, SHAOPENG · 2020 to 2022
$1.1M
NCI NIH HHS R33 CA235294NIGMS NIH HHS R42 GM143986NIGMS NIH HHS R44 GM139535NIH HHS R33CA235294, R44GM139535, R42GM143986
6 · The paper itself

Abstract

The detection and analysis of small molecules, typically defined as molecules under 1000 Da, is of growing interest ranging from the development of small-molecule drugs and inhibitors to the sensing of toxins and biomarkers. However, due to challenges such as their small size and low mass, many biosensing technologies struggle to have the sensitivity and selectivity for the detection of small molecules. Notably, their small size limits the usage of labeled techniques that can change the properties of small-molecule analytes. Furthermore, the capability of real-time detection is highly desired for small-molecule biosensors' application in diagnostics or screening. This review highlights recent advances in label-free real-time biosensing technologies utilizing different types of transducers to meet the growing demand for small-molecule detection.

Indexed as

Biosensing TechniquesBiomarkersNanotechnologyTechnologyTransducersBiomarkersbiosensorelectrochemical transductionlabel-freeoptical transductionpiezoelectric transductionreal-time detectionsmall molecule

Identifiers

PMID38391999
PMCPMC10886562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.