Evidence map›Paper›PMID 38391962›Full record

ArticleCells2024

Real-Time Multiphoton Intravital Microscopy of Drug Extravasation in Tumours during Acoustic Cluster Therapy.

Jessica Lage Fernandez, Sofie Snipstad, Astrid Bjørkøy, Catharina de Lange Davies

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jessica Lage FernandezDepartment of Physics, Norwegian University of Science and Technology, 7034 Trondheim, Norway.
Sofie SnipstadDepartment of Physics, Norwegian University of Science and Technology, 7034 Trondheim, Norway.ORCID 0000-0003-1732-7168
Astrid BjørkøyDepartment of Physics, Norwegian University of Science and Technology, 7034 Trondheim, Norway.
Catharina de Lange DaviesDepartment of Physics, Norwegian University of Science and Technology, 7034 Trondheim, Norway.
Norwegian University of Science and Technology · NO

Funding

Central Norway Regional Health Authority 90270600Centre for Innovative Ultrasound Solutions CIUS 237887
6 · The paper itself

Abstract

Optimising drug delivery to tumours remains an obstacle to effective cancer treatment. A prerequisite for successful chemotherapy is that the drugs reach all tumour cells. The vascular network of tumours, extravasation across the capillary wall and penetration throughout the extracellular matrix limit the delivery of drugs. Ultrasound combined with microbubbles has been shown to improve the therapeutic response in preclinical and clinical studies. Most studies apply microbubbles designed as ultrasound contrast agents. Acoustic Cluster Therapy (ACT

Indexed as

NeoplasmsAcousticsAnimalsContrast MediaIntravital MicroscopyUltrasonographyContrast Mediadorsal window chambersdrug deliveryextravasationintravital microscopymicrobubbles

Identifiers

PMID38391962
PMCPMC10887035
OpenAlexW4391882994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.