ReviewCells2024
A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis.
Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- An Umbrella Review of E-Cigarettes' Impact on Oral Microbiota and Biofilm Buildup.Pathogens (Basel, Switzerland) · 2025Pooled it
- The relationship between adequate keratinized mucosa and peri-implant disease: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Effect of nanogold incorporation into polymethyl methacrylate denture bases on microbial activity in implant-retained mandibular overdentures.International journal of implant dentistry · 2025Trial
- Tissue-level implants in the aesthetic zone: why and how?British dental journal · 2026Article
- Effects of intra-articular injection of dimethyl itaconate combined with systemic vancomycin on periprosthetic joint infection in rats.Bone & joint research · 2026Article
- Article
- Maintenance of Custom-Made Subperiosteal Implants: A Narrative Review of Indirect Evidence and Preliminary Clinical Considerations.Journal of clinical medicine · 2026Review
- Bone and Infections: An Osteoimmunological Interplay.International journal of molecular sciences · 2026Review
- The Role and Progress of Antimicrobial Peptides in Managing Oral Biofilms: A Narrative Review.International dental journal · 2026Review
- Berberine alleviates biofilm-associated immune-inflammatory injury inFrontiers in immunology · 2026Article
- Modulation of osteoclast differentiation by epigallocatechin-3-gallate (EGCG)/type I collagen-coated titanium implant surface in vitro.Journal of dental sciences · 2026Article
- Influence of dental implant surfaces on oral biofilms and host immune response.Journal of oral microbiology · 2026Article
- Influence of the design of modern subperiosteal multivectorial anchored Implants on success and survival in complex patient cases.Scientific reports · 2025Article
- Microbiome Shifts in Peri-Implantitis: Longitudinal Characterization of Dysbiosis and Resolution.International dental journal · 2025Article
- Exploring Peri-Implantitis Risk-Factors: A Cross-Sectional Study.Dentistry journal · 2025Article
- The effects of magnesium-containing coatings on the healing of soft tissues surrounding oral titanium abutments: a narrative review.Frontiers in dental medicine · 2025Review
- Enhancing patient-centered information on implant dentistry through prompt engineering: a comparison of four large language models.Frontiers in oral health · 2025Article
- Comparative Analysis of Osteoblastic Responses to Titanium and Alumina-Toughened Zirconia Implants: An In Vitro Study.Biomolecules · 2024Article
- Indian Society of Periodontology Good Clinical Practice Recommendations for Peri-implant Care.Journal of Indian Society of PeriodontologyReview
- Viral Contributions to Periodontal and Peri-implant Disease: A Narrative Review.Saudi journal of medicine & medical sciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This mapping review highlights the need for a new paradigm in the understanding of peri-implantitis pathogenesis. The biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis is proposed, focusing on the relationship between biofilm, inflammation, and bone biology. The close interactions between immune and bone cells are discussed, with multiple stable states likely existing between clinically observable definitions of peri-implant health and peri-implantitis. The framework presented aims to explain the transition from health to disease as a staged and incremental process, where multiple factors contribute to distinct steps towards a tipping point where disease is manifested clinically. These steps might be reached in different ways in different patients and may constitute highly individualised paths. Notably, factors affecting the underlying biology are identified in the pathogenesis of peri-implantitis, highlighting that disruptions to the host-microbe homeostasis at the implant-mucosa interface may not be the sole factor. An improved understanding of disease pathogenesis will allow for intervention on multiple levels and a personalised treatment approach. Further research areas are identified, such as the use of novel biomarkers to detect changes in macrophage polarisation and activation status, and bone turnover.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.