ReviewJournal of functional biomaterials2024
Surface Functionalization of Titanium-Based Implants with a Nanohydroxyapatite Layer and Its Impact on Osteoblasts: A Systematic Review.
Review in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Dental Resin Composites Modified with Chitosan: A Systematic Review.Marine drugs · 2025Pooled it
- Osteoblast responses to implant materials and the role of vitamin D in dental implant osseointegration: a narrative review.International journal of implant dentistry · 2026Review
- Metal coordination at biological interfaces: Mechanisms, therapeutics, and translation.Materials today. Bio · 2026Review
- Biocompatible Germanium-Enriched Nanocomposite Coatings on Titanium Designed Toward Preventing Early Inflammation and Promoting Osteogenic Differentiation.Journal of functional biomaterials · 2026Article
- Autologous Tissue Grafts for Chin Augmentation With or Without Genioplasty: A Systematic Review.Journal of clinical medicine · 2026Review
- Association Between Cross-Sectional Geometry and Cyclic Fatigue Resistance of Nickel-Titanium Endodontic Instruments: A Systematic Review.Journal of functional biomaterials · 2026Review
- Effects of Additive Incorporation on Fluoride Release of Orthodontic Glass Ionomer Cements and Adhesives: A Systematic Review.Materials (Basel, Switzerland) · 2026Review
- Chitosan-Based Coatings for Orthodontic Appliances: Antimicrobial Properties, Potential Ion-Release Mitigation, and Clinical-Translation Perspectives.Journal of functional biomaterials · 2026Review
- Multiscale Interface Engineering for Orthopedic and Dental Implants: A Review.Journal of functional biomaterials · 2026Review
- Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes.Advanced healthcare materials · 2026Review
- Predictability, Skeletal Stability, and Safety of Iliac Crest Bone Grafts in Large Maxillary Advancement with Le Fort I Osteotomy: A Systematic Review.Journal of clinical medicine · 2026Review
- The Effect of the ErMaterials (Basel, Switzerland) · 2026Article
- SEM Evaluation of Surface Wear on Drills from Selected Implant Systems-In Vitro Study.Materials (Basel, Switzerland) · 2026Article
- Effects of Laser Applications on Fibroblasts Cultured on Zirconia Surfaces-A Systematic Review.Journal of clinical medicine · 2025Review
- Multiscale interface engineering in biohybrid composites for biomedical applications.Materials today. Bio · 2025Review
- The Role of the Oral Microbiome and Dental Caries in Respiratory Health: A Systematic Review.Journal of clinical medicine · 2025Review
- Enhancing Osseointegration of Zirconia Implants Using Calcium Phosphate Coatings: A Systematic Review.Materials (Basel, Switzerland) · 2025Review
- Innovative plasma spray coating of HA-Ti-MgO composite on TiJournal of materials science. Materials in medicine · 2025Article
- Advances of Hydroxyapatite Nanoparticles in Dental Implant Applications.International dental journal · 2025Review
- Bioactive Glass and Melittin Thin Films Deposited by MAPLE for Titanium Implant Functionalization.Materials (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to evaluate the influence of a nanohydroxyapatite layer applied to the surface of titanium or titanium alloy implants on the intricate process of osseointegration and its effect on osteoblast cell lines, compared to uncoated implants. Additionally, the investigation scrutinizes various modifications of the coating and their consequential effects on bone and cell line biocompatibility. On the specific date of November 2023, an exhaustive electronic search was conducted in esteemed databases such as PubMed, Web of Science, and Scopus, utilizing the meticulously chosen keywords ((titanium) AND ((osteoblasts) and hydroxyapatite)). Methodologically, the systematic review meticulously adhered to the PRISMA protocol. Initially, a total of 1739 studies underwent scrutiny, with the elimination of 741 duplicate records. A further 972 articles were excluded on account of their incongruence with the predefined subjects. The ultimate compilation embraced 26 studies, with a predominant focus on the effects of nanohydroxyapatite coating in isolation. However, a subset of nine papers delved into the nuanced realm of its modifiers, encompassing materials such as chitosan, collagen, silver particles, or gelatine. Across many of the selected studies, the application of nanohydroxyapatite coating exhibited a proclivity to enhance the osseointegration process. The modifications thereof showcased a positive influence on cell lines, manifesting in increased cellular spread or the attenuation of bacterial activity. In clinical applications, this augmentation potentially translates into heightened implant stability, thereby amplifying the overall procedural success rate. This, in turn, renders nanohydroxyapatite-coated implants a viable and potentially advantageous option in clinical scenarios where non-modified implants may not suffice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.