Evidence map›Paper›PMID 38391890›Full record

ArticleJournal of functional biomaterials2024

An Anti-Oxidative Bioink for Cartilage Tissue Engineering Applications.

Xin Chen, Mengni Yang, Zheng Zhou, Jingjing Sun, Xiaolin Meng, Yuting Huang, Wenxiang Zhu, Shuai Zhu, Ning He, Xiaolong Zhu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Recent Advances in Silk Fibroin Derived fromJournal of functional biomaterials · 2025
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Xin ChenCollege of Material Science and Engineering, Hunan University, Changsha 410082, China.
Mengni YangCollege of Material Science and Engineering, Hunan University, Changsha 410082, China.
Zheng ZhouCollege of Biology, Hunan University, Changsha 410082, China.ORCID 0000-0003-3397-3290
Jingjing SunCollege of Biology, Hunan University, Changsha 410082, China.
Xiaolin MengCollege of Material Science and Engineering, Hunan University, Changsha 410082, China.
Yuting HuangCollege of Material Science and Engineering, Hunan University, Changsha 410082, China.
Wenxiang ZhuCollege of Material Science and Engineering, Hunan University, Changsha 410082, China.
Shuai ZhuCollege of Material Science and Engineering, Hunan University, Changsha 410082, China.
Ning HeCollege of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China.ORCID 0000-0003-0016-3283
Xiaolong ZhuCollege of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China.
Xiaoxiao HanCollege of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China.
Hairong LiuCollege of Material Science and Engineering, Hunan University, Changsha 410082, China.
Hunan University · CN

Funding

the National Key Research and Development Program of China 2018YFC1105800the National Natural Science Foundation of China 81871767the Natural Science Foundation of Changsha City kq2014040the Natural Science Foundation of Hunan Province 2021JJ30095the Shenzhen Fundamental Research Key Project JCYJ20200109150641992the Shenzhen Key Laboratory of Digital Surgical Printing Project ZDSYS201707311542415
6 · The paper itself

Abstract

Since chondrocytes are highly vulnerable to oxidative stress, an anti-oxidative bioink combined with 3D bioprinting may facilitate its applications in cartilage tissue engineering. We developed an anti-oxidative bioink with methacrylate-modified rutin (RTMA) as an additional bioactive component and glycidyl methacrylate silk fibroin as a biomaterial component. Bioink containing 0% RTMA was used as the control sample. Compared with hydrogel samples produced with the control bioink, solidified anti-oxidative bioinks displayed a similar porous microstructure, which is suitable for cell adhesion and migration, and the transportation of nutrients and wastes. Among photo-cured samples prepared with anti-oxidative bioinks and the control bioink, the sample containing 1 mg/mL of RTMA (RTMA-1) showed good degradation, promising mechanical properties, and the best cytocompatibility, and it was selected for further investigation. Based on the results of 3D bioprinting tests, the RTMA-1 bioink exhibited good printability and high shape fidelity. The results demonstrated that RTMA-1 reduced intracellular oxidative stress in encapsulated chondrocytes under H

Indexed as

3D bioprintingantioxidantbioinkcartilage tissue engineeringrutin

Identifiers

PMID38391890
PMCPMC10889144
OpenAlexW4391486086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.