Evidence map›Paper›PMID 38391713›Full record

ReviewBrain sciences2024

Overview of the Current Knowledge and Conventional MRI Characteristics of Peri- and Para-Vascular Spaces.

Marco Parillo, Federica Vaccarino, Gianfranco Di Gennaro, Sumeet Kumar, Johan Van Goethem, Bruno Beomonte Zobel, Carlo Cosimo Quattrocchi, Paul M Parizel, Carlo Augusto Mallio

Abstract readReview
In one paragraph

Review in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Different Glymphatic Kinetics in Spontaneous Intracranial Hypotension.AJNR. American journal of neuroradiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marco ParilloFondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy.ORCID 0000-0002-4067-7118
Federica VaccarinoFondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy.ORCID 0000-0003-0472-0526
Gianfranco Di GennaroDepartment of Health Sciences, Chair of Medical Statistics, University of Catanzaro "Magna Græcia", 88100 Catanzaro, Italy.ORCID 0000-0002-7204-4091
Sumeet KumarDepartment of Neuroradiology, National Neuroscience Institute, Singapore 308433, Singapore.
Johan Van GoethemDepartment of Radiology, Antwerp University Hospital, 2650 Edegem, Belgium.ORCID 0000-0003-3993-4583
Bruno Beomonte ZobelFondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy.
Carlo Cosimo QuattrocchiCentre for Medical Sciences-CISMed, University of Trento, Via S. Maria Maddalena 1, 38122 Trento, Italy.
Paul M ParizelRoyal Perth Hospital & University of Western Australia, Perth, WA 6000, Australia.ORCID 0000-0002-0221-2854
Carlo Augusto MallioFondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy.ORCID 0000-0002-0149-0801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain spaces around (perivascular spaces) and alongside (paravascular or Virchow-Robin spaces) vessels have gained significant attention in recent years due to the advancements of in vivo imaging tools and to their crucial role in maintaining brain health, contributing to the anatomic foundation of the glymphatic system. In fact, it is widely accepted that peri- and para-vascular spaces function as waste clearance pathways for the brain for materials such as ß-amyloid by allowing exchange between cerebrospinal fluid and interstitial fluid. Visible brain spaces on magnetic resonance imaging are often a normal finding, but they have also been associated with a wide range of neurological and systemic conditions, suggesting their potential as early indicators of intracranial pressure and neurofluid imbalance. Nonetheless, several aspects of these spaces are still controversial. This article offers an overview of the current knowledge and magnetic resonance imaging characteristics of peri- and para-vascular spaces, which can help in daily clinical practice image description and interpretation. This paper is organized into different sections, including the microscopic anatomy of peri- and para-vascular spaces, their associations with pathological and physiological events, and their differential diagnosis.

Indexed as

brain cystsglymphatic systemmagnetic resonance imagingMRIneurofluidsneuroradiologyparavascular spacesperivascular spacesPVSVirchow–Robin spaces

Identifiers

PMID38391713
PMCPMC10886993

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.