Evidence map›Paper›PMID 38391701›Full record

ArticleBrain sciences2024

Velocity-Selective Arterial Spin Labeling Perfusion in Monitoring High Grade Gliomas Following Therapy: Clinical Feasibility at 1.5T and Comparison with Dynamic Susceptibility Contrast Perfusion.

Sebastian Lambrecht, Dapeng Liu, Omar Dzaye, David O Kamson, Jonas Reis, Thomas Liebig, Matthias Holdhoff, Peter Van Zijl, Qin Qin, Doris D M Lin

Abstract read
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sebastian LambrechtRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Dapeng LiuRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Omar DzayeDepartment of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
David O KamsonDepartment of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jonas ReisInstitute of Neuroradiology, University Hospital LMU Munich, 81377 Munich, Germany.ORCID 0000-0001-8932-2265
Thomas LiebigInstitute of Neuroradiology, University Hospital LMU Munich, 81377 Munich, Germany.
Matthias HoldhoffDepartment of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Peter Van ZijlRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Qin QinRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Doris D M LinRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-6001-2383

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Development and Evaluation of Advanced Non-Contrast Perfusion MRI for Monitoring Treatment Response in Brain MetastasesR01CA282928 · NCI · UNIVERSITY OF WASHINGTON · PI QIN, QIN · 2023 to 2025
$1.8M
Velocity-Selective Arterial Spin Labeling based Perfusion Mapping for Cerebrovascular DiseasesR01HL144751 · NHLBI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI QIN, QIN · 2019 to 2022
$1.7M
NCI NIH HHS R01 CA282928NHLBI NIH HHS R01 HL144751NIBIB NIH HHS P41 EB031771
6 · The paper itself

Abstract

MR perfusion imaging is important in the clinical evaluation of primary brain tumors, particularly in differentiating between true progression and treatment-induced change. The utility of velocity-selective ASL (VSASL) compared to the more commonly utilized DSC perfusion technique was assessed in routine clinical surveillance MR exams of 28 patients with high-grade gliomas at 1.5T. Using RANO criteria, patients were assigned to two groups, one with detectable residual/recurrent tumor ("RT", n = 9), and the other with no detectable residual/recurrent tumor ("NRT", n = 19). An ROI was drawn to encompass the largest dimension of the lesion with measures normalized against normal gray matter to yield rCBF and tSNR from VSASL, as well as rCBF and leakage-corrected relative CBV (lc-rCBV) from DSC. VSASL (rCBF and tSNR) and DSC (rCBF and lc-rCBV) metrics were significantly higher in the RT group than the NRT group allowing adequate discrimination (

Indexed as

arterial spin labeling (ASL)dynamic susceptibility contrast (DSC)glioblastomagliomaperfusionvelocity-selective arterial spin labeling (VSASL)

Identifiers

PMID38391701
PMCPMC10886779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.