Evidence map›Paper›PMID 38391684›Full record

ReviewBioengineering (Basel, Switzerland)2024

Tracheal Tissue Engineering: Principles and State of the Art.

Marco Mammana, Alessandro Bonis, Vincenzo Verzeletti, Andrea Dell'Amore, Federico Rea

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Tracheal Tissue Engineering: Advances and Challenges.Bioengineering (Basel, Switzerland) · 2026
    Review
  6. Article
  7. [Application and challenges of tissue engineered scaffolds in treatment of long-segment laryngotracheal stenosis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Engineered Anti-Senescence Trachea With Post-Transplanted Regenerative Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Tissue-Engineered Tracheal Reconstruction.Biomimetics (Basel, Switzerland) · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marco MammanaDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, Italy.
Alessandro BonisDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, Italy.ORCID 0000-0001-9422-0597
Vincenzo VerzelettiDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, Italy.ORCID 0000-0001-7239-1248
Andrea Dell'AmoreDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, Italy.
Federico ReaDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padua, 35128 Padua, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients affected by long-segment tracheal defects or stenoses represent an unsolved surgical issue, since they cannot be treated with the conventional surgery of tracheal resection and consequent anastomosis. Hence, different strategies for tracheal replacement have been proposed (synthetic materials, aortic allografts, transplantation, autologous tissue composites, and tissue engineering), each with advantages and drawbacks. Tracheal tissue engineering, on the other hand, aims at recreating a fully functional tracheal substitute, without the need for the patient to receive lifelong immunosuppression or endotracheal stents. Tissue engineering approaches involve the use of a scaffold, stem cells, and humoral signals. This paper reviews the main aspects of tracheal TE, starting from the choice of the scaffold to the type of stem cells that can be used to seed the scaffold, the methods for their culture and expansion, the issue of graft revascularization at the moment of in vivo implantation, and experimental models of tracheal research. Moreover, a critical insight on the state of the art of tracheal tissue engineering is also presented.

Indexed as

stem cellstissue engineeringtracheatransplantation

Identifiers

PMID38391684
PMCPMC10886658
OpenAlexW4391933266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.