Evidence map›Paper›PMID 38391660›Full record

ArticleBioengineering (Basel, Switzerland)2024

Ultrasound Flow Imaging Study on Rat Brain with Ultrasound and Light Stimulations.

Junhang Zhang, Chen Gong, Zihan Yang, Fan Wei, Xin Sun, Jie Ji, Yushun Zeng, Chi-Feng Chang, Xunan Liu, Deepthi S Rajendran Nair and 2 more

Open access · goldAbstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Junhang ZhangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-7847-3102
Chen GongDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Zihan YangCaruso Department of Otolaryngology-Head & Neck Surgery, University of Southern California, Los Angeles, CA 90033, USA.
Fan WeiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0009-0003-0652-4841
Xin SunDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0009-0002-6292-6776
Jie JiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Yushun ZengDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-5995-4085
Chi-Feng ChangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Xunan LiuDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Deepthi S Rajendran NairDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.
Biju B ThomasDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-0312-4450
Qifa ZhouDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
University of Southern California · US

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
High Resolution Elastograpy of Retina Under Prosthetic Electrical StimulationR01EY026091 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, ZHOU, QIFA · 2016 to 2019
$2.0M
Non-invasive Ultrasound Stimulated Retinal ProsthesisR01EY030126 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHOU, QIFA · 2019 to 2022
$2.0M
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY026091NEI NIH HHS R01 EY028662NEI NIH HHS R01 EY030126
6 · The paper itself

Abstract

Functional ultrasound (fUS) flow imaging provides a non-invasive method for the in vivo study of cerebral blood flow and neural activity. This study used functional flow imaging to investigate rat brain's response to ultrasound and colored-light stimuli. Male Long-Evan rats were exposed to direct full-field strobe flashes light and ultrasound stimulation to their retinas, while brain activity was measured using high-frequency ultrasound imaging. Our study found that light stimuli, particularly blue light, elicited strong responses in the visual cortex and lateral geniculate nucleus (LGN), as evidenced by changes in cerebral blood volume (CBV). In contrast, ultrasound stimulation elicited responses undetectable with fUS flow imaging, although these were observable when directly measuring the brain's electrical signals. These findings suggest that fUS flow imaging can effectively differentiate neural responses to visual stimuli, with potential applications in understanding visual processing and developing new diagnostic tools.

Indexed as

blood flow imagingretinal stimulationultrasound stimulation

Identifiers

PMID38391660
PMCPMC10886342
OpenAlexW4391752735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.