Evidence map›Paper›PMID 38391569›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Antibacterial Activity and Cytotoxicity Screening of Acyldepsipeptide-1 Analogues Conjugated to Silver/Indium/Sulphide Quantum Dots.

Sinazo Z Z Cobongela, Maya M Makatini, Bambesiwe May, Zikhona Njengele-Tetyana, Mokae F Bambo, Nicole R S Sibuyi

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sinazo Z Z CobongelaHealth Platform, Advanced Materials Division, Mintek, Randburg 2194, South Africa.ORCID 0000-0001-9057-3096
Maya M MakatiniMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Johannesburg 2050, South Africa.ORCID 0000-0001-7280-0945
Bambesiwe MayDepartment of Science and Innovation (DSI)/Mintek Nanotechnology Innovation Centre (NIC), Advanced Materials Division, Mintek, Randburg 2194, South Africa.
Zikhona Njengele-TetyanaHealth Platform, Advanced Materials Division, Mintek, Randburg 2194, South Africa.
Mokae F BamboDepartment of Science and Innovation (DSI)/Mintek Nanotechnology Innovation Centre (NIC), Advanced Materials Division, Mintek, Randburg 2194, South Africa.ORCID 0000-0003-1437-724X
Nicole R S SibuyiHealth Platform, Advanced Materials Division, Mintek, Randburg 2194, South Africa.ORCID 0000-0001-7175-5388
Mintek · ZAUniversity of South Africa · ZAUniversity of the Witwatersrand · ZA

Funding

DSI/NIC ADE 42305Mintek Science Vote ADR 42304
6 · The paper itself

Abstract

The continuous rise in bacterial infections and antibiotic resistance is the driving force behind the search for new antibacterial agents with novel modes of action. Antimicrobial peptides (AMPs) have recently gained attention as promising antibiotic agents with the potential to treat drug-resistant infections. Several AMPs have shown a lower propensity towards developing resistance compared to conventional antibiotics. However, these peptides, especially acyldepsipeptides (ADEPs) present with unfavorable pharmacokinetic properties, such as high toxicity and low bioavailability. Different ways to improve these peptides to be drug-like molecules have been explored, and these include using biocompatible nano-carriers. ADEP1 analogues (SC005-8) conjugated to gelatin-capped Silver/Indium/Sulfide (AgInS

Indexed as

acyldepsipeptidesadamantaneAgInS2 quantum dotsanionic peptidesantibacterial peptidesnano-carriersnanomaterialspalmitic acid

Identifiers

PMID38391569
PMCPMC10886425
OpenAlexW4391822133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.