Evidence map›Paper›PMID 38391475›Full record

ArticleGels (Basel, Switzerland)2024

Polydopamine Blending Increases Human Cell Proliferation in Gelatin-Xanthan Gum 3D-Printed Hydrogel.

Preetham Yerra, Mario Migliario, Sarah Gino, Maurizio Sabbatini, Monica Bignotto, Marco Invernizzi, Filippo Renò

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Preetham YerraHealth Sciences Department, Università del Piemonte Orientale, Via Solaroli n.17, 28100 Novara, Italy.
Mario MigliarioTraslational Medicine Department, Università del Piemonte Orientale, Via Solaroli n.17, 28100 Novara, Italy.ORCID 0000-0003-1627-4164
Sarah GinoHealth Sciences Department, Università del Piemonte Orientale, Via Solaroli n.17, 28100 Novara, Italy.ORCID 0000-0001-9415-4788
Maurizio SabbatiniDepartment of Sciences and Innovative Technology, Università del Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, Italy.
Monica BignottoDepartment of Health Sciences, Università degli Studi di Milano, Via A. di Rudini n.8, 20142 Milano, Italy.ORCID 0000-0002-2043-7846
Marco InvernizziHealth Sciences Department, Università del Piemonte Orientale, Via Solaroli n.17, 28100 Novara, Italy.
Filippo RenòDepartment of Health Sciences, Università degli Studi di Milano, Via A. di Rudini n.8, 20142 Milano, Italy.ORCID 0000-0003-2410-4966
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Milan · IT

Funding

University of Eastern Piedmont Amadeo Avogadro RIVinvernizzimRL16_BCRLrehab17_19,University of Eastern Piedmont Amadeo Avogadro RIVsabbatinimFAR17_astrociti_19-21.
6 · The paper itself

Abstract

backgroundGelatin-xanthan gum (Gel-Xnt) hydrogel has been previously modified to improve its printability; now, to increase its ability for use as cell-laden 3D scaffolds (bioink), polydopamine (PDA), a biocompatible, antibacterial, adhesive, and antioxidant mussel-inspired biopolymer, has been added (1-3%

methodsControl (CT) and PDA-blended hydrogels were used to print 1 cm RESULTS AND DISCUSSION: PDA blending did not modify the hydrogel printability or physiochemical characteristics, suggesting that PDA did not interfere with GTA crosslinking. On the other hand, PDA presence strongly accelerated and increased both fibroblast and keratinocyte growth inside. This effect seemed to be linked to the adhesive abilities of PDA, which improve cell adhesion and, in turn, proliferation.

conclusionsThe simple PDA blending method described could help in obtaining a new bioink for the development of innovative 3D-printed wound dressings.

Indexed as

bioprintingcell proliferationfibroblasthydrogelkeratinocytepolydopamineskin wound healing

Identifiers

PMID38391475
PMCPMC10888377
OpenAlexW4391822799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.