Evidence map›Paper›PMID 38391438›Full record

ArticleGels (Basel, Switzerland)2024

Bioactive Polyurethane-Poly(ethylene Glycol) Diacrylate Hydrogels for Applications in Tissue Engineering.

Yixuan Yuan, Caleb Tyson, Annika Szyniec, Samuel Agro, Tara N Tavakol, Alexander Harmon, DessaRae Lampkins, Lauran Pearson, Jerald E Dumas, Lakeshia J Taite

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yixuan YuanDepartment of Chemical Engineering, University of Virginia, Charlottesville, VA 22903, USA.
Caleb TysonDepartment of Chemical Engineering, Hampton University, Hampton, VA 23668, USA.
Annika SzyniecDepartment of Chemical Engineering, University of Virginia, Charlottesville, VA 22903, USA.
Samuel AgroDepartment of Chemical Engineering, University of Virginia, Charlottesville, VA 22903, USA.
Tara N TavakolDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Alexander HarmonDepartment of Chemical Engineering, Hampton University, Hampton, VA 23668, USA.
DessaRae LampkinsDepartment of Chemical Engineering, Hampton University, Hampton, VA 23668, USA.
Lauran PearsonDepartment of Chemical Engineering, Hampton University, Hampton, VA 23668, USA.
Jerald E DumasJoint School of Nanoscience and Nanoengineering, North Carolina Agricultural & Technical State University, Greensboro, NC 27401, USA.
Lakeshia J TaiteDepartment of Chemical Engineering, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0001-5420-6483
University of Virginia · USHampton University · USNorth Carolina Agricultural and Technical State University · US

Funding

National Science Foundation 1700351National Science Foundation 1827820
6 · The paper itself

Abstract

Polyurethanes (PUs) are a highly adaptable class of biomaterials that are among some of the most researched materials for various biomedical applications. However, engineered tissue scaffolds composed of PU have not found their way into clinical application, mainly due to the difficulty of balancing the control of material properties with the desired cellular response. A simple method for the synthesis of tunable bioactive poly(ethylene glycol) diacrylate (PEGDA) hydrogels containing photocurable PU is described. These hydrogels may be modified with PEGylated peptides or proteins to impart variable biological functions, and the mechanical properties of the hydrogels can be tuned based on the ratios of PU and PEGDA. Studies with human cells revealed that PU-PEG blended hydrogels support cell adhesion and viability when cell adhesion peptides are crosslinked within the hydrogel matrix. These hydrogels represent a unique and highly tailorable system for synthesizing PU-based synthetic extracellular matrices for tissue engineering applications.

Indexed as

cell adhesionhydrogelsphotocrosslinkingpoly(ethylene glycol) diacrylatepolyurethanescaffoldstissue engineering

Identifiers

PMID38391438
PMCPMC10887679
OpenAlexW4391322729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.