Evidence map›Paper›PMID 38391431›Full record

ArticleGels (Basel, Switzerland)2024

Clinical Perspectives on the Injectability of Cross-Linked Hyaluronic Acid Dermal Fillers: A Standardized Methodology for Commercial Product Benchmarking with Inter-Injector Assessments.

Patrick Micheels, Alexandre Porcello, Thierry Bezzola, Daniel Perrenoud, Pierre Quinodoz, Yogeshvar Kalia, Eric Allémann, Alexis Laurent, Olivier Jordan

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Cross-Linked Versus Linear Hyaluronic Acid for Cartilage Repair in Rat Post-Traumatic Osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Patrick MicheelsPrivate Medical Practice, CH-1224 Chêne-Bougeries, Switzerland.
Alexandre PorcelloSchool of Pharmaceutical Sciences, University of Geneva, CH-1211 Geneva, Switzerland.ORCID 0000-0003-1603-2704
Thierry BezzolaPrivate Medical Practice, CH-1204 Geneva, Switzerland.
Daniel PerrenoudPrivate Medical Practice, CH-1006 Lausanne, Switzerland.
Pierre QuinodozHôpital de la Tour, CH-1217 Meyrin, Switzerland.
Yogeshvar KaliaSchool of Pharmaceutical Sciences, University of Geneva, CH-1211 Geneva, Switzerland.ORCID 0000-0001-9049-5489
Eric AllémannSchool of Pharmaceutical Sciences, University of Geneva, CH-1211 Geneva, Switzerland.ORCID 0000-0002-6598-9521
Alexis LaurentRegenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0001-5738-8702
Olivier JordanSchool of Pharmaceutical Sciences, University of Geneva, CH-1211 Geneva, Switzerland.ORCID 0000-0003-3752-2198
University of Geneva · CHHôpital de la Tour · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The injectability of cross-linked hyaluronic acid (HA) dermal fillers is influenced by polymer concentration, polymer cross-linking type and degree, the presence of lidocaine or other functional excipients, types of syringes, and injection techniques. Finished product injectability constitutes a critical quality attribute for clinical injectors, as it strongly influences product applicability and ease of use in aesthetic medicine. While injectable product extrusion force specifications are provided by the respective device manufacturers, the qualitative informative value of such datasets is low for injectors wishing to compare product brands and technologies from an injectability standpoint. Therefore, the present study comparatively assessed 28 cross-linked HA dermal fillers (JUVÉDERM

Indexed as

aesthetic medicinecross-linked hyaluronic aciddermal fillersex vivo skinhydrogel systemsinjectabilitylidocainemedical deviceneedle gaugeproduct benchmarking

Identifiers

PMID38391431
PMCPMC10888303
OpenAlexW4391263562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.