Evidence map›Paper›PMID 38391402›Full record

ArticleClinics and practice2024

Phytotherapy Might Have a Role in Reducing Unnecessary Prostate Biopsies: Results from an Exploratory, Randomized Controlled Trial of Two Different Phytotherapeutic Agents.

Tommaso Cai, Irene Tamanini, Marco Puglisi, Leonardo Bizzotto, Michele Rizzo, Giovanni Liguori, Luca Gallelli, Alessandro Palmieri, Truls E Bjerklund Johansen

Open access · goldAbstract read
In one paragraph

Article in Clinics and practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Tommaso CaiDepartment of Urology, Santa Chiara Regional Hospital, 38122 Trento, Italy.ORCID 0000-0002-7234-3526
Irene TamaniniDepartment of Urology, Santa Chiara Regional Hospital, 38122 Trento, Italy.
Marco PuglisiDepartment of Urology, Santa Chiara Regional Hospital, 38122 Trento, Italy.
Leonardo BizzottoCentro Servizi Sanitari (CST), 38121 Trento, Italy.
Michele RizzoDepartment of Urology, University of Trieste, 34127 Trieste, Italy.
Giovanni LiguoriDepartment of Urology, University of Trieste, 34127 Trieste, Italy.
Luca GallelliDepartment of Health Science, School of Medicine, University of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0003-0858-7902
Alessandro PalmieriDepartment of Urology, University of Naples Federico II, 80138 Naples, Italy.
Truls E Bjerklund JohansenInstitute of Clinical Medicine, University of Oslo, 0313 Oslo, Norway.ORCID 0000-0003-3490-6460
Ospedale Santa Chiara · ITUniversity of Trieste · ITOslo University Hospital · NOUniversity of Naples Federico II · ITUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to evaluate the impact of two different phytotherapeutic agents on decision making regarding prostate biopsy for patients with higher-than-normal prostate-specific antigen (PSA) levels.

methodsFrom June 2022 to May 2023, all patients attending two urological institutions due to higher-than-normal PSA levels were randomized to receive either oral capsules of Curcuma Longa, Boswellia, Pinus pinaster and Urtica dioica (Group A) or Serenoa Repens 320 mg (Group B) for 3 months. At the follow-up visit after 3 months, all patients underwent PSA tests and multiparametric magnetic resonance imaging (mpMRI).

resultsIn the per-protocol analysis, data from 66 patients in Group A and 76 in Group B were analyzed. Fifty patients in Group A (75.7%) showed a significant reduction in total PSA compared to forty-nine in Group B (64.4%) (

conclusionsIn conclusion, a three-month course of a combination of Curcuma Longa, Boswellia, Pinus pinaster and Urtica dioica seems to be an interesting tool to avoid unnecessary prostate biopsies among men with higher-than-normal PSA levels.

Indexed as

diagnosisinflammationphytotherapyprostate cancerprostate-specific antigen

Identifiers

PMID38391402
PMCPMC10888467
OpenAlexW4391132500

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.