Evidence map›Paper›PMID 38391311›Full record

Observational studyRadiology. Imaging cancer2024

Quantitative US Delta Radiomics to Predict Radiation Response in Individuals with Head and Neck Squamous Cell Carcinoma.

Laurentius Oscar Osapoetra, Archya Dasgupta, Daniel DiCenzo, Kashuf Fatima, Karina Quiaoit, Murtuza Saifuddin, Irene Karam, Ian Poon, Zain Husain, William T Tran and 2 more

Open access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Radiology. Imaging cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Laurentius Oscar Osapoetra *From the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.ORCID 0000-0001-9278-0953
Archya Dasgupta *From the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.ORCID 0000-0001-8341-2622
Daniel DiCenzoFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.
Kashuf FatimaFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.
Karina QuiaoitFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.
Murtuza SaifuddinFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.
Irene KaramFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.
Ian PoonFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.
Zain HusainFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.
William T TranFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.
Lakshmanan SannachiFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.ORCID 0000-0002-9775-0224
Gregory J CzarnotaFrom the Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.), Medical Oncology (W.T.T.), and Medicine (W.T.T.), Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5; Departments of Radiation Oncology (L.O.O., A.D., I.K., I.P., Z.H., W.T.T., G.J.C.) and Medical Biophysics (G.J.C.), University of Toronto, Toronto, Canada; and Departments of Physical Sciences (L.O.O., A.D., D.D., K.F., K.Q., M.S., L.S., G.J.C.) and Evaluative Clinical Sciences (W.T.T.), Sunnybrook Research Institute, Toronto, Canada.
Sunnybrook Health Science Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To investigate the role of quantitative US (QUS) radiomics data obtained after the 1st week of radiation therapy (RT) in predicting treatment response in individuals with head and neck squamous cell carcinoma (HNSCC). Materials and Methods This prospective study included 55 participants (21 with complete response [median age, 65 years {IQR: 47-80 years}, 20 male, one female; and 34 with incomplete response [median age, 59 years {IQR: 39-79 years}, 33 male, one female) with bulky node-positive HNSCC treated with curative-intent RT from January 2015 to October 2019. All participants received 70 Gy of radiation in 33-35 fractions over 6-7 weeks. US radiofrequency data from metastatic lymph nodes were acquired prior to and after 1 week of RT. QUS analysis resulted in five spectral maps from which mean values were extracted. We applied a gray-level co-occurrence matrix technique for textural analysis, leading to 20 QUS texture and 80 texture-derivative parameters. The response 3 months after RT was used as the end point. Model building and evaluation utilized nested leave-one-out cross-validation. Results Five delta (Δ) parameters had statistically significant differences (

Indexed as

Head and Neck NeoplasmsAgedFemaleHumansMaleMiddle AgedNeckProspective StudiesRadiomicsSquamous Cell Carcinoma of Head and NeckComputer-Aided Diagnosis (CAD)Head and Neck Squamous Cell CarcinomaHead/NeckMachine LearningQuantitative USRadiation Therapy/OncologyRadiomicsRadiotherapyUltrasound

Identifiers

PMID38391311
PMCPMC10988345
OpenAlexW4392100000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.