Evidence map›Paper›PMID 38391257›Full record

Trial reportThe journal of spinal cord medicine2025

Neuropathic pain development and maintenance and its association with motor recovery after cervical spinal cord injury.

Kosuke Saita, Masahiko Sumitani, Yurie Koyama, Shurei Sugita, Yoshitaka Matsubayashi, Toru Ogata, Hiroshi Ohtsu, Hirotaka Chikuda, OSCIS Investigators

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of spinal cord medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Kosuke SaitaDepartment of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan.
Masahiko SumitaniDepartment of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan.ORCID 0000-0002-3662-8217
Yurie KoyamaSchool of Nursing, Kitasato University, Kanagawa, Japan.
Shurei SugitaDepartment of Orthopaedic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Yoshitaka MatsubayashiDepartment of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Toru OgataDepartment of Rehabilitation Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Hiroshi OhtsuNational Center for Global Health and Medicine, Tokyo, Japan.
Hirotaka ChikudaDepartment of Orthopaedic Surgery, Gunma University, Gunma, Japan.
OSCIS InvestigatorsThe Japanese Orthopaedic Association, Tokyo, Japan.
University of Tokyo Hospital · JPGunma University · JPKitasato University · JPNational Center for Global Health and Medicine · JPTokyo Metropolitan Komagome Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn our published randomized controlled trial, we revealed that patients with acute ASIA Grade C incomplete cervical spinal cord injury (SCI) who underwent early surgery (within 24 h post-injury) had accelerated motor recovery at six months than those with delayed surgery (>2 weeks post-injury); however, neuropathic pain (NeP) worsened regardless of surgery timing. Here, we conducted

methodsOf 44 patients (median 64.5 years; three female; early intervention,

resultsUpper and lower limb motor impairments were comparable between both groups regardless of pain severity. Severe at-level pain remained stable and worsened at one year than mild at-level pain; however, the upper- and lower-limb motor scores and HRQOL had comparable recovery. Background characteristics did not affect severity or time course of NeP. Patients with severe below-level pain demonstrated slower lower-limb motor recovery than those with mild below-level pain, whereas HRQOL improved regardless of pain severity.

conclusionsBoth at-level and below-level NeP developed and persisted relatively early in the course of traumatic SCI with incomplete motor paralysis; their severities worsened over time or remained severe since onset.

Indexed as

Cervical CordNeuralgiaRecovery of FunctionSpinal Cord InjuriesAdultAgedFemaleHumansMaleMiddle AgedQuality of LifeAcute cervical spinal cord injuryAt-level painBelow-level painMotor recoveryNeuropathic pain

Identifiers

PMID38391257
PMCPMC12499529
OpenAlexW4392110931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.