Evidence map›Paper›PMID 38390562›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Assessment of circulating apoE4 levels from dried blood spot samples in a large survey setting.

Nis Borbye-Lorenzen, Yacila I Deza-Lougovski, Solveig Holmgaard, Luzia M Weiss, Marie Bækvad-Hansen, Kristin Skogstrand, Anna Rieckmann, Axel Börsch-Supan, Martina Börsch-Supan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Nis Borbye-LorenzenDepartment of Congenital Disorders Center for Neonatal Screening, Statens Serum Institut Copenhagen Denmark.ORCID https://orcid.org/0000-0003-3725-4533
Yacila I Deza-LougovskiInstitute of Psychology University of the Bundeswehr München Neubiberg Germany.ORCID https://orcid.org/0000-0002-2624-077X
Solveig HolmgaardDepartment of Congenital Disorders Center for Neonatal Screening, Statens Serum Institut Copenhagen Denmark.
Luzia M WeissMax Planck Institute for Social Law and Social Policy Munich Germany.
Marie Bækvad-HansenDepartment of Congenital Disorders Center for Neonatal Screening, Statens Serum Institut Copenhagen Denmark.ORCID https://orcid.org/0000-0002-5881-1776
Kristin SkogstrandDepartment of Congenital Disorders Center for Neonatal Screening, Statens Serum Institut Copenhagen Denmark.ORCID https://orcid.org/0000-0002-0026-3711
Anna RieckmannInstitute of Psychology University of the Bundeswehr München Neubiberg Germany.ORCID https://orcid.org/0000-0002-5389-1578
Axel Börsch-SupanMax Planck Institute for Social Law and Social Policy Munich Germany.ORCID https://orcid.org/0000-0003-0470-8850
Martina Börsch-SupanThe Munich Research Institute for the Economics of Aging and SHARE Analyses (MEA) Munich Germany.ORCID https://orcid.org/0000-0002-1826-4018
Statens Serum Institut · DKUniversität der Bundeswehr München · DEMax Planck Institute for Social Law and Social Policy · DENational Bureau of Economic Research · US

Funding

Bio-medical and socio-economic precursors of cognitive decline in SHARER01AG056329 · NIA · MAX PLANCK INST/SOCIAL LAW/SOCIAL POLICY · PI BOERSCH-SUPAN, AXEL H · 2017 to 2021
$4.1M
Understanding Cross-National Health Differences at Older Ages and Their CausesR01AG063944 · NIA · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI BOERSCH-SUPAN, AXEL H, CRIMMINS, EILEEN M · 2019 to 2024
$3.2M
Enhancing the Comparability of SHARE with HRS and ELSAR01AG052527 · NIA · MAX PLANCK INST/SOCIAL LAW/SOCIAL POLICY · PI BOERSCH-SUPAN, AXEL H · 2016 to 2020
$2.1M
NIA NIH HHS HHSN271201300071CNIA NIH HHS R01 AG052527NIA NIH HHS R01 AG056329NIA NIH HHS R01 AG063944
6 · The paper itself

Abstract

introductionThe apolipoprotein E (

methodsWe developed a multiplex immunoassay to detect apoE4 protein levels in DBS from 15,974 participants, aged 50+ from Wave 6 of the Survey of Health, Ageing and Retirement in Europe (SHARE).

resultsThe apoE4 protein signal was presented in two separable distributions. One distribution corresponded to carriers of at least one copy of the ε4 allele. Fieldwork cofounders affected protein levels but did not explain individual differences. DISCUSSION: Future research should investigate how genotype and apoE4 level interact with lifestyle and other variables to impact cognitive aging.

Indexed as

Ageing and Retirement in EuropeAlzheimer's diseaseapolipoprotein E ε4dried blood spotsSurvey of Healthsurvey research

Identifiers

PMID38390562
PMCPMC10883237
OpenAlexW4392041333

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.