ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Geospatial environmental complexity, spatial brain volume, and spatial behavior across the Alzheimer's disease spectrum.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Environmental enrichment: a systematic review on the effect of a changing spatial complexity on hippocampal neurogenesis and plasticity in rodents, with considerations for translation to urban and built environments for humans.Frontiers in neuroscience · 2024Pooled it
- Humanised Environmental Enrichment: Spatial Effects of Cities and Buildings on Adult Hippocampal Neurogenesis in Humans.International journal of molecular sciences · 2026Review
- Neurobiophilia.Brain sciences · 2026Review
- Comparative analysis of maze complexity: implications for adult hippocampal neurogenesis.Frontiers in neuroscience · 2026Article
- A novel early screening approach for MCI due to AD based on a "maze" hand-interaction kinetic paradigm.Frontiers in neuroscience · 2026Article
- Walking and Hippocampal Formation Volume Changes: A Systematic Review.Brain sciences · 2025Review
- The BDNF-Interactive Model for Sustainable Hippocampal Neurogenesis in Humans: Synergistic Effects of Environmentally-Mediated Physical Activity, Cognitive Stimulation, and Mindfulness.International journal of molecular sciences · 2024Review
- Housing Environmental Enrichment, Lifestyles, and Public Health Indicators of Neurogenesis in Humans: A Pilot Study.International journal of environmental research and public health · 2024Article
- Borderline in a linear city: Urban living brings borderline personality disorder to crisis through neuroplasticity-an urgent call to action.Frontiers in psychiatry · 2024Article
- Neurosustainability.Frontiers in human neuroscience · 2024Article
- Geospatial environmental complexity, spatial brain volume, and spatial behavior across the Alzheimer's disease spectrum.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
introductionUnderstanding impact of environmental properties on Alzheimer's disease (AD) is paramount. Spatial complexity of one's routinely navigated environment is an important but understudied factor.
methodsA total of 660 older adults from National Alzheimer's Coordinating Center (NACC) dataset were geolocated and environmental complexity index derived from geospatial network landmarks and points-of-interest. Latent models tested mediation of spatial navigation-relevant brain volumes and diagnosis (cognitively-healthy, mild cognitive impairment [MCI], AD) on effect of environmental complexity on spatial behavior.
resultsGreater environmental complexity was selectively associated with larger allocentric (but not egocentric) navigation-related brain volumes, lesser diagnosis of MCI and AD, and better spatial behavioral performance, through indirect hierarchical mediation. DISCUSSION: Findings support hypothesis that spatially complex environments positively impact navigation neural circuitry and spatial behavior function. Given the vulnerability of these very circuits to AD pathology, residing in spatially complex environments may be one factor to help stave off the brain atrophy that accompanies spatial navigation deficits across the AD spectrum.
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