Evidence map›Paper›PMID 38390528›Full record

ArticleBioactive materials2024

Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor.

Congyi Shen, Jian Wang, Guangfeng Li, Shuyue Hao, Yan Wu, Peiran Song, Yafei Han, Mengmeng Li, Guangchao Wang, Ke Xu and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
57.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 123 citations in OpenAlex.

  1. Review
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  4. Applications of DNA Hydrogels in Osteoporotic Bone Defects.Journal of functional biomaterials · 2026
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Congyi ShenInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Jian WangInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Guangfeng LiInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Shuyue HaoInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Yan WuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Peiran SongInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Yafei HanInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Mengmeng LiInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Guangchao WangDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Ke XuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Hao ZhangInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Xiaoxiang RenInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Yingying JingInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Ru YangSecond Affiliated Hospital of Soochow University, Departments of Rheumatology and Immunology, Soochow, 215000, China.
Zhen GengInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Jiacan SuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Shanghai University · CNShanghai Jiao Tong University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA), a common degenerative disease, is characterized by high disability and imposes substantial economic impacts on individuals and society. Current clinical treatments remain inadequate for effectively managing OA. Organoids, miniature 3D tissue structures from directed differentiation of stem or progenitor cells, mimic native organ structures and functions. They are useful for drug testing and serve as active grafts for organ repair. However, organoid construction requires extracellular matrix-like 3D scaffolds for cellular growth. Hydrogel microspheres, with tunable physical and chemical properties, show promise in cartilage tissue engineering by replicating the natural microenvironment. Building on prior work on SF-DNA dual-network hydrogels for cartilage regeneration, we developed a novel RGD-SF-DNA hydrogel microsphere (RSD-MS) via a microfluidic system by integrating photopolymerization with self-assembly techniques and then modified with Pep-RGDfKA. The RSD-MSs exhibited uniform size, porous surface, and optimal swelling and degradation properties.

Indexed as

Cartilage organoidCartilage repairChondrogenesisMicrosphereSilk fibroin-DNA hydrogel

Identifiers

PMID38390528
PMCPMC10881360
OpenAlexW4391876712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.