Evidence map›Paper›PMID 38390374›Full record

ArticleMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention2023

Modularity-Constrained Dynamic Representation Learning for Interpretable Brain Disorder Analysis with Functional MRI.

Qianqian Wang, Mengqi Wu, Yuqi Fang, Wei Wang, Lishan Qiao, Mingxia Liu

Abstract read
In one paragraph

Article in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qianqian WangDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Mengqi WuDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Yuqi FangDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Wei WangDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Lishan QiaoSchool of Mathematics Science, Liaocheng University, Shandong 252000, China.
Mingxia LiuDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Funding

Multi-Site Neuroimage Harmonization for Personalized Brain Disorder AnalysisRF1AG073297 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2022 to 2022
$1.4M
NIA NIH HHS RF1 AG073297
6 · The paper itself

Abstract

Resting-state functional MRI (rs-fMRI) is increasingly used to detect altered functional connectivity patterns caused by brain disorders, thereby facilitating objective quantification of brain pathology. Existing studies typically extract fMRI features using various machine/deep learning methods, but the generated imaging biomarkers are often challenging to interpret. Besides, the brain operates as a modular system with many cognitive/topological modules, where each module contains subsets of densely inter-connected regions-of-interest (ROIs) that are sparsely connected to ROIs in other modules. However, current methods cannot effectively characterize brain modularity. This paper proposes a modularity-constrained dynamic representation learning (MDRL) framework for interpretable brain disorder analysis with rs-fMRI. The MDRL consists of 3 parts: (1) dynamic graph construction, (2) modularity-constrained spatiotemporal graph neural network (MSGNN) for dynamic feature learning, and (3) prediction and biomarker detection. In particular, the MSGNN is designed to learn spatiotemporal dynamic representations of fMRI, constrained by 3 functional modules (

Indexed as

BiomarkerBrain disorderFunctional MRIModularity

Identifiers

PMID38390374
PMCPMC10883232

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.