Evidence map›Paper›PMID 38389892›Full record

ArticleRSC medicinal chemistry2024

Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking.

Joseph Hennessy, Piotr Klimkowski, Daniel Singleton, Alex Gibney, Malou Coche, Nicholas P Farrell, Afaf H El-Sagheer, Tom Brown, Andrew Kellett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Accessing New Phenanthroline-Oxazine Scaffolds as Copper-Dependent DNA Damaging Probes.Chembiochem : a European journal of chemical biology · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joseph HennessySSPC, The Science Foundation Ireland Research Centre for Pharmaceuticals, School of Chemical Sciences, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie.ORCID https://orcid.org/0000-0001-7625-3803
Piotr KlimkowskiChemistry Research Laboratory, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK.
Daniel SingletonATDBio Ltd., School of Chemistry, University of Southampton Southampton SO17 1BJ UK.
Alex GibneySSPC, The Science Foundation Ireland Research Centre for Pharmaceuticals, School of Chemical Sciences, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie.ORCID https://orcid.org/0000-0001-8541-8796
Malou CocheSSPC, The Science Foundation Ireland Research Centre for Pharmaceuticals, School of Chemical Sciences, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie.
Nicholas P FarrellDepartment of Chemistry, Virginia Commonwealth University Richmond VA 23284-2006 USA.ORCID https://orcid.org/0000-0001-7160-7182
Afaf H El-SagheerChemistry Research Laboratory, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK.
Tom BrownChemistry Research Laboratory, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK.ORCID https://orcid.org/0000-0002-6538-3036
Andrew KellettSSPC, The Science Foundation Ireland Research Centre for Pharmaceuticals, School of Chemical Sciences, Dublin City University Glasnevin Dublin 9 Ireland andrew.kellett@dcu.ie.ORCID https://orcid.org/0000-0002-8947-1401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a new class of carboplatin-TFO hybrid that incorporates a bifunctional alkyne-amine nucleobase monomer called AP-C3-dT that enables dual 'click' platinum(ii) drug conjugation and thiazole orange fluorophore coupling. Thiazole orange enhances the binding of Pt(ii)-TFO hybrids and provides an intrinsic method for monitoring triplex formation. These hybrid constructs possess increased stabilisation and crosslinking properties in comparison to earlier Pt(ii)-TFOs, and demonstrate sequence-specific binding at neutral pH.

Identifiers

PMID38389892
PMCPMC10880910

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.