Evidence map›Paper›PMID 38389883›Full record

ArticleRSC medicinal chemistry2024

Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators.

Yingpeng Liu, Radosław P Nowak, Jianwei Che, Katherine A Donovan, Fidel Huerta, Hu Liu, Rebecca J Metivier, Eric S Fischer, Lyn H Jones

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yingpeng LiuCenter for Protein Degradation, Dana-Farber Cancer Institute Boston MA USA lyn_jones@dfci.harvard.edu.
Radosław P NowakCenter for Protein Degradation, Dana-Farber Cancer Institute Boston MA USA lyn_jones@dfci.harvard.edu.ORCID https://orcid.org/0000-0002-0605-0071
Jianwei CheCenter for Protein Degradation, Dana-Farber Cancer Institute Boston MA USA lyn_jones@dfci.harvard.edu.
Katherine A DonovanDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Boston MA USA.
Fidel HuertaCenter for Protein Degradation, Dana-Farber Cancer Institute Boston MA USA lyn_jones@dfci.harvard.edu.
Hu LiuCenter for Protein Degradation, Dana-Farber Cancer Institute Boston MA USA lyn_jones@dfci.harvard.edu.
Rebecca J MetivierDepartment of Cancer Biology, Dana-Farber Cancer Institute Boston MA USA.
Eric S FischerCenter for Protein Degradation, Dana-Farber Cancer Institute Boston MA USA lyn_jones@dfci.harvard.edu.ORCID https://orcid.org/0000-0001-7337-6306
Lyn H JonesCenter for Protein Degradation, Dana-Farber Cancer Institute Boston MA USA lyn_jones@dfci.harvard.edu.ORCID https://orcid.org/0000-0002-8388-5865
Harvard University · USDana-Farber Cancer Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sulfonyl fluoride EM12-SF was developed previously to covalently engage a histidine residue in the sensor loop of cereblon (CRBN) in the E3 ubiquitin ligase complex CRL4

Identifiers

PMID38389883
PMCPMC10880902
OpenAlexW4391492413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.